These reactions are typically catalysed by enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) activity. Acetylation is the process where an acetyl functional group is transferred from one molecule (in this case, acetyl coenzyme A) to another.

Recent studies have proposed various regulatory mechanisms for histone acetylation and deacetylation on gene activity. Several evidences have shown that HAT or HDAC enzymes are stepwise recruited to a specific locus by various types of transcription factors.

Aug 13, 2007 · Effects of histone acetyltransferase (HAT) and histone deacetylase (HDAC) inhibitors on proliferative, differentiative, and regenerative functions of Toll-like receptor 2 (TLR-2)-stimulated human...

Feb 27, 2007 · Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two counteracting enzyme families whose enzymatic activity controls the acetylation state of protein lysine residues,...

Histone acetylation induced by histone acetyl transferases (HATs) is associated with gene transcription, while histone hypoacetylation induced by histone deacetylase (HDAC) activity is associated with gene silencing.

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc- or NAD + -dependent mechanisms to …

Oct 28, 2005 · Histone acetyltransferases (HATs) and histone deacetylases (HDACs) represent two enzyme classes that, respectively, catalyze forward and backward reaction kinetics of lysine residue acetylation...

Apr 8, 2024 · The most recent therapeutic methods involve the use of small molecules known as histone deacetylase (HDAC) inhibitors that antagonize HDAC activity thereby increase acetylation levels in order to prevent the loss of HAT function in neurodegenerative disorders.

Besides the transcription-promoting role of histone acetyltransferases (HATs) and the transcription-delimiting function of histone deacetylases (HDACs) through histone acetylation and deacetylation respectively, HATs and HDACs also regulate the activity of …

Aug 6, 2021 · Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate the addition and removal of acetyl groups from lysine residues on histones respectively. Nuclear factor (NF)‑κB, tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 are the pro‑inflammatory genes known to promote inflammatory responses in cells.