Here we summarise these observations and propose that secretion of IL-1β occurs on a continuum, dependent upon stimulus strength and the extracellular IL-1β requirement. …

In chondrogenic ATDC5 cells, IL-1β decreases the levels of aggrecan and type II collagen but significantly increased the metalloproteinase-13 (Mmp13) mRNA by real-time reverse …

Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein …

Jan 18, 2010 · IL-1 family members promote the activity of cells of the innate immune system, such as neutrophils, eosinophils, basophils, mast cells and natural killer cells. IL-1 family …

A dimeric configuration of HD5 has been documented as the most functionally active form, wherein each monomer is linked through a β2 strand (Fig 1A and 1B), while an HD5 tetramer …

May 16, 2019 · This study identifies a new function for IL-1β in the onset or enhancement of cell-intrinsic immunity, with important implications for cGAS-STING in integrating inflammatory and …

Aug 29, 2010 · Interleukin 1β (IL-1β) is a key orchestrator of inflammation and host defense that exerts its effects through IL-1 receptor type I (IL-1RI) and IL-1 receptor accessory protein (IL …

Interleukin (IL)-1b is the most potent pro-inflammatory cytokine secreted unconventionally from monocytes and macrophages to initiate an inflammatory response.

IL-1b Maturation Is Necessary and Sufficient for Slow IL-1b Secretion, while Rapid Secretion Requires Caspase-1 and GSDMD Caspase1 is required for both the maturation and secretion …

Evidence for the involvement of IL-1β and the clinical results of reducing IL-1β activity in this broad spectrum of inflammatory diseases are the focus of this review.