Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. [5] [6] [7] [8] There are four HCN channels. HCN4 is …

Mar 30, 2025 · HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4) is a Protein Coding gene. Diseases associated with HCN4 include Sick Sinus Syndrome 2 and …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are integral membrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of …

The HCN4 gene provides instructions for making a channel that transports positively charged atoms (ions) into heart muscle cells. This channel is located primarily in the sino-atrial (SA) …

Feb 21, 2025 · Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) drives the funny current in cardiac pacemaker regions. Its involvement in sinoatrial node pacemaker …

Feb 8, 2025 · A novel mutation is found in HCN4 gene causing symptoms of sinus bradycardia in unrelated male Moroccan Jews. These findings suggest HCN4 as a genetic susceptibility …

Nov 3, 2020 · We addressed this question using a knockin mouse line expressing cyclic adenosine monophosphate-insensitive HCN4 channels. This mouse line displayed a complex …

Jun 6, 2013 · We found that the earliest HCN4 expression marks the first heart field, and that HCN4 is dynamically expressed in distinct differentiated cardiomyocyte precursors at different …

The HCN4 gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated ion channel family, which are expressed at the cell membrane and contribute to the resting …

Feb 8, 2025 · HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 Gene ID: 10021, updated on 8-Feb-2025 Gene type: protein coding Also known as: SSS2; …