Feb 15, 2023 · As one of the main members of the tumor microenvironment (TME) of HCC, tumor-associated macrophages (TAMs) play a critical role in its occurrence and development, including stimulating...

Tumor-associated macrophages (TAMs) actively participate in tumor-related inflammation, representing the main type of inflammatory cells in the tumor microenvironment, setting the crosstalk between tumor and stromal cells. Infiltrating TAMs exert either anti-tumorigenic (M1) or pro-tumorigenic (M2) functions.

Aug 24, 2024 · Evidence has shown that TAMs play a crucial role in HCC, through its interaction with other immune cells in the TME. This review summarizes the origin and phenotypic polarization of TAMs, their potential impacts on HCC, and their mechanisms and potential targets for HCC immunotherapy.

Aug 28, 2019 · This article reviews studies on the role of TAM to affect HCC treatment and provides insight into the potential individualized precision monotherapy or combination therapy in HCC.

TAMs can produce cytokines, induce EMT in HCC cells, and enhance CSC characteristics, thus improving the ability of invasion and metastasis. In the margins of human HCC, there is a positive correlation between the number of TAM and the density of CSC.

Sep 6, 2024 · The TAM polarization in HCC tumors is M2. Both direct and indirect methods for TAMs to regulate the development of HCC are discussed. TAMs indirectly support HCC development by promoting peripheral angiogenesis and regulating the …

Jul 12, 2024 · Tumor-associated macrophages (TAMs) play a significant role in the tumor microenvironment of hepatocellular carcinoma (HCC), with a predominant M2 polarization contributing to tumor...

As one of the main members of the tumor microenvironment (TME) of HCC, tumor-associated macrophages (TAMs) play a critical role in its occurrence and development, including stimulating angiogenesis, enhancing immunosuppression, and promoting the …

May 1, 2022 · Current targeting TAMs to treat HCC have been achieved a promising therapeutic outcome by eliminating TAMs present, blocking recruitment of TAMs, reprogramming TAMs polarization, modulating TAMs products and restoring TAMs phagocytic capacity.

Tumor-associated macrophages (TAMs) inhepatocellularcarcinoma (HCC) play a prominent role in tumormicroenvironment by presenting M1 (induced by IFN γ along with LPS) and M2 (induced by IL-4 and IL13) polarization.