NCI-H460 [H460] cells were isolated in 1982 from the pleural fluid of a male patient with large cell lung cancer. Use these cells in your cancer and toxicology research.

Establishment and characterization of a topotecan resistant non-small cell lung cancer NCI-H460/TPT10 cell line. Front. Cell Dev. Biol. 8:607275.1-607275.10(2020)

NCI-H460 lung cancer cells possess an epithelial morphology. NCI-H460 is a tumorigenic cell line with a hypotriploid karyotype. The modal chromosome number for these cells is 57. NCI-H460 cells also possess 58 modal chromosome numbers at comparable rates.

H460 cells are a faster growing cell line, with a growth rate almost double that of A549 cells. As a result, HPRT expression on the surface of non-small-cell lung cancer cells may directly correspond to cell proliferation.

Aliases: LC:NCI-H460, NCI-H460, NCIH460, H460, CVCL_0459; Tissue: Lung; Cellosaurus: CVCL_0459; NCI-H460 is in CellMinerCDB, a searchable tool integrating cancer cell line pharmacogenomics data to link gene and drug activity signatures.

NCI-H460 is one of the most widely utilized cell line models for studying non-small cell lung cancer (NSCLC), offering researchers a valuable tool for investigating cancer biology, drug responses, and developing novel therapeutic approaches.

细胞描述：人大细胞肺癌细胞NCI-H460 [H460]由A.F. Gazdar 于1982 年建立， 来源于一位大细胞肺癌患者的胸腔积液。 该细胞与正常肺组织p53 mRNA 的表

The H460 xenograft model is an established human non-small cell lung cancer (NSCLC) model derived from the NCI-H460 cell line, which originates from a large cell lung carcinoma. It is widely used in preclinical oncology studies to evaluate the efficacy of anticancer therapeutics, including chemotherapy, targeted therapies, and immunotherapies.

NCI-H460细胞系是1982年由A.F. Gazdar从一位男性大细胞肺癌患者的胸腔积液（胸水）中分离，来源于肺癌的转移灶，而非原发肿瘤。 NCI-H460细胞是亚三倍体，通常显示模态染色体数为57条，偶尔会出现58条。

NCI-H460: Human Large Cell Lung Carcinoma Epithelial Cell Line, Established from the Pleural effusion (metastatic site) of a Caucasian, male patient