Aug 11, 2024 · Currently, 3 FDA-approved H2RAs are available in the United States, either over-the-counter (OTC) or by prescription. Famotidine and cimetidine are available OTC or by prescription, depending on the dose. Low-dose nizatidine is also available in OTC, but higher doses require a prescription.

In several studies, healing rates with H2RAs can be summarized: 50% @ 4 weeks, 43 to 58% @ 6 weeks, 67 to 82% @ 12 weeks. Healing rates are faster in patients with less severe GERD. ∗∗ This product is now covered by Medicaid in its OTC formulation by prescription only.

Recommended Dosage – Ranitidine1 Indication Dose Gastroesophageal reflux disease (GERD), prevention of recurrence. Other indications e.g. Zollinger-Ellison, erosive esophagitis • 150 mg PO BID • See product monograph Renal impairment • CrCl 10-15 mL/min: max 150 mg PO per day • CrCl < 10 mL/min: 75-150 mg PO per day

H2 antagonists block histamine-induced gastric acid secretion from the parietal cells of the gastric mucosa (lining of the stomach). H2 antagonists are used to treat gastroesophageal reflux disease (GERD), gastrointestinal ulcers and other gastrointestinal hypersecretory conditions.

Table 1 shows the recommended doses of ranitidine, famotidine, and nizatidine histamine (H 2)-receptor antagonists (H 2 RAs) for the management of people with gastro-oesophageal reflux disease (GORD).

Oct 1, 2003 · For the empiric trial, treatment may be initiated with a standard dosage of a histamine H 2 -receptor antagonist (H2RA) taken twice daily on demand or a standard dosage of a proton pump...

Sep 1, 2017 · Active ulcer: Oral: 800 mg orally at bedtime or 300mg orally four times daily or 400 mg orally twice daily. IM/IV: 300mg every 6 hours or 37.5 mg/hr continuous infusion. Active bleed: 37.5 mg/hr continuous IV (maximum 2400mg/day). Maintanance (duodenal ulcer prophylaxis): 400mg orally at bedtime.

Consider non-urgent upper gastrointestinal endoscopy to assess for oesophago-gastric cancer in people with haematemesis. For the management of un-investigated dyspepsia use clinical judgement to offer either pylori “test-and-treat” or full dose PPI for one month. The stool antigen test is the preferred pylori test across Derbyshire.

Jan 25, 2018 · Intravenous and intramuscular forms are available for cimetidine, ranitidine and famotidine. The four H2 receptor blockers available in the United States have similar spectra of activity, side effects and clinical indications.

Jan 19, 2017 · Our analysis indicated that the full/standard dose of esomeprazole at 40 mg per day was the most efficient in healing among nine different dosages of PPIs and H2RAs.