A lichen planus-like eruption and poikiloderma (skin atrophy, pigmentary changes, telangiectasia) are the most typical eruptions in the nonsclerotic chronic GVHD setting.

Jun 10, 2021 · Dermatologic manifestations are an important aspect of graft versus host disease (GVHD). Because the skin often is the earliest organ affected in GVHD, dermatologists are crucial members of the...

Itchy skin, dry mouth, diarrhoea, dry eyes, reduced vitality, and psychological stress are the most commonly reported symptoms of GVHD. What are the complications of graft-versus-host disease? Impaired sleep due to itchy skin involvement. Genital involvement can …

Skin GVHD can increase your risk of developing skin cancer. Report any new or changing spots on your skin to your doctor. Protect your skin from exposure to the sun. Remember that the sun’s rays can be just as damaging on a cool, cloudy day as they are on a hot, sunny day.

Chronic GVHD of the skin can cause color changes (red, pink, purple, brown or white), thinning or thickening, hardening, rashes, scaly areas, bumps, sores or blisters (small pockets of fluid).

Oct 31, 2024 · The skin is often the first organ affected by cGVHD. Key symptoms include: Rashes or Redness: New or unusual rashes may appear on the arms, legs, chest, or back. Dryness or Scaling: Persistent dryness or peeling can mimic eczema or other skin conditions.

Acute skin GVHD is staged as follows: (1) <25% body surface area (BSA); (2) 25–50% BSA; (3) >50% BSA or erythroderma, and (4) erythroderma with bullae. Similar staging of hepatic and gastrointestinal aGVHD based on bilirubin elevation, quantity of diarrhea and presence of pain/ileus is used to determine an overall aGVHD grade.

Apr 25, 2024 · Cutaneous manifestations of acute skin GVHD include a morbilliform eruption (Figure 1 A), which can progress to desquamation and bullae formation in severe (e.g., grade IV) cases (Figure 1 B) [19].

Mar 28, 2025 · Cutaneous manifestations of graft-versus-host disease (GvHD) are the most common complication of allogeneic hematopoietic stem cell transplantation. We delineate the acute and chronic forms of GvHD, emphasizing their distinct clinical presentations, with acute GvHD commonly manifesting as a morbilliform rash and chronic GvHD exhibiting poikiloderma, lichenoid, and sclerodermoid changes. The ...

Acute GVHD may cause itchy, dry, and sensitive skin, along with a flat or slightly raised rash. Chronic GVHD can lead to darkened, thickened, or bumpy skin and may also cause skin to become thin and fragile. Typically, acute graft-versus-host disease produces a rash that has flat and raised areas.