In this Perspective, we provide an overview of currently available mouse models of acute and chronic GvHD, highlighting their benefits and limitations, and discuss research and clinical …

Jun 7, 2024 · Graft-versus-host disease (GVHD) is a systemic disorder occurring when immune cells from transplanted tissue recognize the recipient's body as foreign and attack its cells. In …

This study shows that CD4 + T cells can mediate GVHD in MHC-mismatched transplants without contacting recipient non-haematopoietic tissues.

GVHD is a major complication in allogeneic bone marrow transplantation (BMT). MHC class I mismatching increases GVHD, but in MHC-matched BMT minor histocompatibility antigens …

A complete understanding of the HLA barrier in graft-versus-host disease (GVHD) after unrelated donor HCT requires an appreciation of the unique features of the classical HLA genes, non …

Graft-versus-host disease (GVHD), induced by the reaction of donor T cells to recipient histoincompatible antigens, is a serious complication of allogeneic bone marrow …

Beta2m(-/-) mice accepted MHC class I-expressing BM grafts and developed significant GVHD. MHC (H-2)-mismatched recipients developed acute lethal GVHD. In contrast, animals …

Feb 28, 2009 · Acute GVHD is responsible for 15% to 40% of mortality and is the major cause of morbidity after allogeneic HCT, while chronic GVHD occurs in up to 50% of patients who …

Sep 12, 2013 · Recent information on the major histocompatibility complex (MHC) region of chromosome 6 as an important source of untyped genetic variation has shed light on novel …

Jan 3, 2025 · MHC class II molecules on enterocytes have the ability to expose recipient T cells to donor-derived antigens, triggering an immunological response that results in GVHD. The gut …