Fundamental research using mouse models of GvHD should enhance our understanding of GvHD in humans and result in improved and novel therapeutic approaches to minimize GvHD while …

The stable and reliable approaches of humanized animal models are crucial for advancing on the study the biology of GVHD. Relative models transplanting the human immune cells into the …

Charles River offers allogeneic and xenogeneic preclinical Graft vs Host Disease (GVHD) mouse models. The GvHD model can be used to model the disease side effect of hematopoietic stem …

Sep 26, 2019 · Aiming for a higher translational value, we constructed an MHC major mismatched [C57BL/6 (H-2 Kb) to BALB/c (H-2Kd)] aGVHD mouse model based on …

Nov 29, 2018 · The traditional animal model of GVHD is based on TBI conditioning regimen prior to allo-HSCT. However, the process can lead to systemic adverse reactions such as …

Murine GVHD experiments have been utilized to model the clinical disorders of acute and chronic GVHD (AGVHD and CGVHD) that occur after allogeneic bone marrow transplantation, and …

Oct 1, 2023 · Although dogs have also played a major role in GVHD research, mice are currently the most commonly used animal model for GVHD because of the advantages of ease of …

In this Perspective, we provide an overview of currently available mouse models of acute and chronic GvHD, highlighting their benefits and limitations, and discuss research and clinical …

Nov 29, 2018 · There are two types of GvHD: acute (aGvHD) and chronic (cGvHD), which have different parthenogenesis and phenotype. aGvHD typically involves skin, gastrointestinal and …

Jun 23, 2016 · In this study, we discuss several clinical approaches that were motivated by preclinical evidence, novel NHP models and their advantages, and highlight the recent …