Jun 11, 2021 · The two most common tests for determining metabolic health in mice are the glucose tolerance test (GTT) and insulin tolerance test (ITT).

In mice, the GTT is the simplest, and usually the first, test applied to an animal model, and it provides a physiological overview of any changes in glucose tolerance without determining the …

The GTT measures changes in blood glucose concentration over a 2-h period following the administration of a bolus of glucose. However, this simplicity belies several important …

Fast mice overnight for approximately 16 hours by transferring mice to clean cages with no food or faeces in hopper or bottom of cage. Ensure that they have access to drinking water at all …

Dec 1, 2008 · We conclude that 2 g/kg glucose administered orally following 6 h of fasting is best to assess glucose tolerance in mice under these conditions. type 2 diabetes is characterized …

We conclude that 2 g/kg glucose administered orally following 6 h of fasting is best to assess glucose tolerance in mice under these conditions. The objective of this study was to determine …

To establish the impact of sex, dosing route, fasting duration and acute habituation stress on glucose tolerance test (GTT) measurements used in the preclinical evaluation of potential …

GTT provides information on glucose homeostasis in mice and their capacity to secrete insulin during the test. Fasting glucose and fasting insulin measurements should be plotted as a bar …

Mar 17, 2020 · Here, we describe in detail how to perform a GTT using four different routes of glucose administration: intraperitoneal, oral, voluntary oral, and intravenous. The glucose …

Nov 25, 2024 · Glucose tolerance tests (GTT) and insulin tolerance tests (ITT) are by far the most common and simple metabolic tests used by researchers to assess glucose homeostasis and …