Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN).

Mar 30, 2025 · GSK3A (Glycogen Synthase Kinase 3 Alpha) is a Protein Coding gene. Diseases associated with GSK3A include Alzheimer's Disease and Ureteral Obstruction. Among its related pathways are IL-9 Signaling Pathways and Activation of cAMP-Dependent PKA.

Nov 27, 2021 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility?

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues.

glycogen synthase kinase-3 alpha, GSK-3 alpha, serine/threonine-protein kinase GSK3A. Targeting Gsk3a reverses immune evasion to enhance immunotherapy in hepatocellular carcinoma. GSK3: A potential target and pending issues for treatment of Alzheimer's disease.

Glycogen synthase kinase-3 (GSK-3) is a critical serine (S)/threonine (T) kinase which phosphorylates numerous proteins [1]. These phosphorylation events often result in the inactivation of the proteins by targeting them for proteasomal degradation.

Jun 19, 2013 · GSK-3 gene family consists of two highly conserved kinases: GSK-3α and GSK-3β. GSK3A encodes a protein of 51 kDa, whereas GSKB encodes a protein of 47 kDa. 23 GSK-3α has a glycine-rich extension...

GSK3β plays important roles in the pathogenesis of cancer, while GSK3α has long been considered a functionally redundant protein of GSK3β. Few studies have specifically investigated the functions of GSK3α.

Glycogen Synthase Kinase 3 (GSK3) is one of the Serine/Threonine protein kinases, which has gained a lot of attention for its role in a variety of pathways. It has two isoforms, GSK3α and GSK3β. However, GSK3β is highly expressed in different areas of the brain and has been implicated in Alzheimer's disease as it is involved in tau phosphorylation.

Glycogen synthase kinase (GSK) 3 is a serine/threonine kinase consisting of two highly similar paralogs, GSK3α and β. With more than 40 definitely identified targets and more than 500 proposed candidate substrates, GSK3 is involved in the regulation of a plethora of intracellular/molecular, organic/cellular, and (patho-)physiological events [1].