Mar 18, 2024 · Here we show that circulating lactate levels positively correlate with the degree of body weight loss in male and female patients suffering from cancer cachexia, as well as in …

Recent studies showed that the physiological functions of GPR81 include lipid metabolism in adipose tissues, metabolic excitability in the brain, cellular development, and inflammatory …

Sep 15, 2014 · GPR81 is a lactate receptor recently identified in adipose and muscle cells that has not been investigated in cancer. In the current study, we examined GPR81 expression …

Apr 15, 2022 · Here, we show that GPR81 regulates the malignant phenotype of breast cancer cell by reprogramming energy metabolism. We found that GPR81 is highly expressed in breast …

GPR81 is a cell-surface G-protein coupled receptor with high homology to GPR109a and GPR109b (1, 2). GPR81 is expressed at a relatively high level in fat cells and at lower levels in …

Aug 21, 2023 · GPR81 is a widely distributed receptor that binds L-lactate and acts as a metabolic sensor. In the brain, GPR81 couples energy metabolism, synaptic activity, and blood flow. We …

GPR81 is often termed the hydroxycarboxylic acid receptor 1 (HCAR1) (Mosienko et al., 2015). GPR81 can be activated by lactate in the range of 0.1–30 mM which corresponds to …

Feb 2, 2022 · Herein, we hypothesize that lactate via its G-protein coupled receptor (GPR81) controls postnatal brain angiogenesis and plays a protective role after HI injury. We show that …

Apr 7, 2010 · Here we show that lactate activates the G protein-coupled receptor GPR81, which is expressed in adipocytes and mediates antilipolytic effects through G (i)-dependent inhibition of …

Apr 28, 2020 · Recent studies showed that the physiological functions of GPR81 include lipid metabolism in adipose tissues, metabolic excitability in the brain, cellular development, and …