Furthermore, we show that GR acts both as a direct inhibitor of CREB binding protein (CBP)-associated HAT activity and also by recruiting HDAC2 to the p65-CBP HAT complex. This …

We identified the glucocorticoid receptor (GR) as being responsible for that downregulation, and suggested a correlation between GR and HDAC2 inhibition after VPA treatment, as evidenced …

Mar 5, 2019 · We hypothesized that HDAC2 helps to keep GR in an inactive state in the cytoplasm, and that VPA treatment allows GR translocation in the nucleus. To this aim, we …

Oct 1, 2019 · Glucocorticoid receptor-α (GR-α) and histone deacetylase 2 (HDAC2) play critical roles in the sensitivity to corticosteroid therapy; however, it is unclear whether HDAC2 and/or …

HDAC2 is responsible for the deacetylation of the N-terminal of histone H3 and H4, leading to a more compacted chromatin structure and transcriptional gene silencing (16,17). HDAC2 …

This would mean that the observed long-term reduction in HDAC2 expression in COPD patients has a different origin. The group led by Barnes identified HDAC2 as an important regulator of …

Oct 10, 2006 · The present work has revealed a critical role for Brg1 (Figs. 1, 2) in trans-repression involving GR, NGFI-B, and HDAC2. Brg1 is required for in vivo recruitment of GR …

Jan 1, 2006 · We show that a defect of glucocorticoid receptor (GR) deacetylation caused by impaired histone deacetylase (HDAC) 2 induces glucocorticoid insensitivity toward nuclear …

Jan 23, 2006 · We show that a defect of glucocorticoid receptor (GR) deacetylation caused by impaired histone deacetylase (HDAC) 2 induces glucocorticoid insensitivity toward nuclear …

Moreover, the high level of corticosterone caused by PCE reduced the H3K9ac level on TGFβR1 promoter region through acting on glucocorticoids receptor (GR) and recruiting histone …