GPR50 is the mammalian ortholog of melatonin receptor Mel1c described in non-mammalian vertebrates. [9] Certain polymorphisms of the GPR50 gene in females are associated with increased risk of developing bipolar affective disorder, major depressive disorder, and schizophrenia. [10] .

Aug 15, 2024 · We herein describe that G protein-coupled receptor 50 (GPR50) is a novel mitophagy receptor, which harbors the LC3-interacting region (LIR) and is required in mitophagy under stress...

This review presents current knowledge regarding the function of GPR50 receptor in brain, with a focus on role of this receptor in the hypothalamus-pituitary-adrenal (HPA) axis and the glucocorticoid receptor (GR) signaling, leptin signaling, adaptive thermogenesis, torpor, neurite outgrowth, and self-renewal and neuronal differentiation of ...

GPR50, an orphan GPCR, heterodimerizes constitutively and specifically with MT(1) and MT(2) melatonin receptors; Results describe sequence variants in the melatonin-related receptor gene (GPR50) that associate with circulating triglyceride and HDL levels.

Mar 17, 2025 · Here, we generated GPR50 knockout (GPR50-KO) mice and show that the absence of GPR50 increases neurite outgrowth, cell motility and migration of isolated neural progenitor cells (NPCs) and hypothalamic radial glial cells (tanycytes).

Mar 30, 2025 · GPR50 (G Protein-Coupled Receptor 50) is a Protein Coding gene. Diseases associated with GPR50 include Pituitary Adenoma 2, Growth Hormone-Secreting and X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Eicosanoid ligand-binding receptors.

Apr 4, 2021 · Title: The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development. Pre-eclampsia (PE) plasma IgG1 anti-Epstein-Barr virus nuclear antigen 1 (EBNA-1) antibody cross-reacts with placental protein G protein-coupled receptor 50 (GPR50).

Feb 1, 2023 · The G protein-coupled receptor 50 (GPR50) gene is a member of the GPCRs implicated in antiproliferative effects, and poor survival prognosis is related to the low expression of GPR50 in breast cancer.

Aug 15, 2024 · GPR50-deficient mice exhibit impaired social recognition, which is rescued by prenatal treatment with mitoQ, a mitochondrially antioxidant. The present study identifies GPR50 as a novel mitophagy receptor that is required to maintain mitochondrial OXPHOS in …

GPR50 as a novel mitophagy receptor that is required to maintain mitochondrial OXPHOS in developing neurons. Mitochondria, as the powerhouse of eukaryotic cells, supply neurons with energy by...