Feb 1, 2025 · Allicin kills bacteria and tumor cells through amplified disulfidptosis mediated by GOx-catalyzing glucose starvation. Combination of allicin and GOx also disrupts cellular redox homeostasis, causing ferroptosis.

To further demonstrate whether 3-MA-enhanced tumor starvation therapy is through cell autophagy, we then detected the autophagy using Western blot, immunofluorescence, and Bio-TEM in 4T1 cells treated with DMON@GOx and DMON@GOx/3-MA.

Jul 6, 2020 · In this system, GOx can effectively catalyze the oxidation of glucose to generate H 2 O 2, while pPt triggers the decomposition of both endogenous and exogenous H 2 O 2 to produce considerable content of O 2 to facilitate the glucose consumption by GOx.

Jul 11, 2023 · Combing the GOx-mediated starvation therapy, Cu 2+-related GSH depletion and •OH generation, and DOX-induced chemotherapy, the PGC-DOX effectively inhibited the 4T1 tumor growth by both intratumoral and intravenous administration.

Apr 1, 2024 · We report a new perspective on COF-enhanced ROS generation in sonodynamic therapy (SDT). We design COFs with ferriporphyrin-based building blocks and loading glucose oxidase (GOx) combined with the advantages of COFs in the field of catalysis and gas exchange.

Aug 1, 2022 · Herein, we developed metformin (Met) and glucose oxidase (GOx) co-loaded manganese silicon nanoplatform MnSiO3@Met@GOx (MMG) for TME-responsive ATP dual inhibited starvation/chemodynamic synergistic therapy.

As shown in Figure 4B and E, compared with other groups, the strongest fluorescence signals were found in 4T1 cells incubated with GOx. This phenomenon could be attributed to the continuous consumption of intracellular oxygen during GOx-mediated glucose oxidation.

The GTZ@Z-RBM NPs morphology, drug, and GOx loading/releasing abilities, system toxicity, multimodal synergistic therapy, and tumor metastasis suppression were investigated. The in vitro and in vivo outcomes of GTZ@Z-RBM NPs were assessed in 4T1 breast cancer cells.

Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting immune responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal therapy (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic “cold” tumor microenvironment.

Sep 21, 2021 · The in vivo results demonstrated that GOx/BSO@CS PVs exhibit a good inhibitory effect on the growth of 4T1 tumors in mice. Thus, this work provides a facile strategy to prepare pH-sensitive nanomedicine for synergistic starvation-ferroptosis therapy of tumor.