Glutaredoxin 2 (GLRX2) is an enzyme that in humans encoded by the GLRX2 gene. GLRX2, also known as GRX2, is a glutaredoxin family protein and a thiol-disulfide oxidoreductase that maintains cellular thiol homeostasis.

Mar 30, 2025 · Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.

Feb 8, 2025 · Glutaredoxin 2 Protein (Grx2) as an Independent Prognostic Factor Associated with the Survival of Colon Adenocarcinoma Patients.

While Glrx1 seems to play an important role in preserving mitochondrial integrity, thereby preventing complex I activity loss, GLRX2 could restore complex I activity in mitochondria by catalyzing the deglutathionylation of Cys residues .

Feb 8, 2025 · Glutaredoxin 2 prevents H (2)O (2)-induced cell apoptosis by protecting complex I activity in the mitochondria. Wu H, et al. Biochim Biophys Acta, 2010 Oct. PMID 20547138, Free PMC Article. In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2. Hoff KG, et al. Chem Biol, 2009 Dec 24. PMID 20064440.

Jan 15, 2024 · Glutaredoxin 2 (Grx2; Glrx2) is an enzyme that is of special interest in cancer research. It has been found that Grx2 can act as a backup for the reduction in Trx when cells are exposed to electrophiles that are strong inhibitors of thioredoxin reductase (TrxR).

Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.

Mar 5, 2024 · Glutaredoxin 2a, a mitochondrial isoform, plays a protective role in a human cell line under serum deprivation. Glutaredoxin 2 prevents H (2)O (2)-induced cell apoptosis by protecting complex I activity in the mitochondria. In vivo fluorescent detection of Fe-S …

Sep 14, 2016 · Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.

Glutaredoxins (e.g., GLRX; 600443) are a family of glutathione-dependent hydrogen donors that participate in a variety of cellular redox reactions. By searching an EST database for sequences similar to GLRX, Lundberg et al. (2001) identified cDNAs encoding 2 isoforms of GLRX2, GLRX2A and GLRX2B.