GLI2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. …

Mar 30, 2025 · GLI2 (GLI Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with GLI2 include Culler-Jones Syndrome and Holoprosencephaly 9. Among its related …

The SMO-β-arrestin complex inhibits both cAMP-dependent PKA and CK1, blocking the phosphorylation and proteolytic cleavage of GLI2/3. The full-length GLI proteins are active and …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer.

Dec 13, 2021 · GLI2 is 1 of 3 vertebrate transcription factors implicated as obligatory mediators of Sonic hedgehog (SHH; 600725) signal transduction. Diminished SHH signaling is associated …

Feb 19, 2025 · Herein, we identified the Hedgehog transcription factor, GLI2, as a key node of tumor-mediated immune evasion and immunotherapy resistance during MT. GLI2 generated …

GLI family zinc finger protein 2 promotes skin fibroblast proliferation and DNA damage repair by targeting the miR-200/ataxia telangiectasia mutated axis in diabetic wound healing. TGF …

Feb 1, 2013 · The GLI2 gene encodes one of the three zinc finger transcription factors that are involved in Hedgehog signaling. It was identified by using GLI1 cDNA as a probe (Ruppert et. …

Expression of GLI2 in human keratinocytes led to repression of epidermal differentiation-associated genes under conditions that normally promote epidermal differentiation. 29 …

Oct 11, 2018 · GLI2 binds to the ARHGEF16 promoter and activates gene transcription. Glioma cells U87 and U118 overexpressing ARHGEF16 showed enhanced migration and proliferation …