Aug 11, 2014 · Our data reveal that the suppression of Hh signaling in the absence of cellular contacts is independent of primary cilia and is mediated by the YAP oncogene. Overexpression of YAP blocks Hh...

The transcriptional coactivators yes-associated protein (Yap) and transcriptional coactivator with PDZ-binding motif (Taz) function as mechanosensors in cancer cells and have been implicated in the regulation of myofibroblasts in the kidney.

Nov 6, 2024 · With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to summarize the roles and underlying mechanisms of YAP in glia and glia-related neurological diseases in an integrated perspective.

In a UUO-release model, induction of Gli1 + cell-specific Yap/Taz knockout partially reversed the development of interstitial fibrosis.

Our findings established a novel signaling mechanism by which the interaction between Gli1 and YAP1 promotes ESCC cell growth. This signaling regulation of the tumorigenesis provides a new therapeutic strategy for highly lethal ESCC. Keywords: Gli1; YAP1; esophageal squamous cell carcinoma; tumorigenesis.

Nov 30, 2024 · In this review, we summarise the evidence on how YAP and TAZ are activated in epidermal keratinocytes; how YAP/TAZ-mediated signalling cooperates with other signalling molecules at the plasma membrane, cytoplasmic, and nuclear levels; and how YAP/TAZ ultimately controls transcription programmes, defining epidermal cell fate.

Aug 2, 2017 · In a UUO-release model, induction of Gli1 (+) cell-specific Yap/Taz knockout partially reversed the development of interstitial fibrosis.

Jul 7, 2024 · This study examines the interaction between the HH/GLI and Hippo/YAP signaling pathways in the pathogenesis of BCC and the establishment of an immunosuppressive tumor microenvironment (TME). The study used 3D human organotypic skin models and humanized mouse models to demonstrate that co-activation of HH/GLI and Hippo/YAP in epidermal cells ...

Apr 1, 2022 · In cardiac fibroblasts, Yap/Taz mediate proliferation, myofibroblast differentiation, and pro-inflammatory signaling including the secretion of cytokines and chemokines that contribute to enhanced immune cell recruitment. Following MI, Yap/Taz are activated in macrophages present in the heart.

May 1, 2019 · Taken together, our results demonstrate that YAP/Gli2 promotes VEGFA expression and tumor angiogenesis in RCC cells, which could provide novel therapeutic targets in RCC treatment.