Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]

The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for obesity. However, the exact molecular mechanisms responsible for the effect of FTO on obesity remain largely unknown.

The fat mass and obesity-associated (FTO) gene was the first obesity-susceptibility gene identified through a genome-wide association study (GWAS). A growing number of studies have suggested that genetic variants of FTO are strongly associated with ...

The fat mass and obesity-associated (FTO) gene, identified by genome-wide association studies (GWAS), was first reported to be positively associated with obesity in humans. Mice with more copies of the FTO gene were observed to be obese, while loss of the gene in mice was found to protect from obesity.

Mar 30, 2025 · FTO (FTO Alpha-Ketoglutarate Dependent Dioxygenase) is a Protein Coding gene. Diseases associated with FTO include Growth Retardation, Developmental Delay, And Facial Dysmorphism and Body Mass Index Quantitative Trait Locus 14.

Jul 20, 2021 · What is the FTO Gene? The FTO gene was identified in 2007 in a genome-wide association study that looked at over 35,000 people to determine genes involved in obesity. Variants in the gene are strongly linked to the likelihood of having a higher BMI. But…

Mar 22, 2023 · Fat mass and obesity-associated gene (FTO) is the first gene discovered which has a close connection with fat. Recent studies suggested that FTO gene has played an important role in the molecular mechanisms of many diseases.

In this review, we explore the genetic epidemiology of FTO and discuss how its complex biology might link to the regulation of body weight.

The FTO gene is located at chromosome 16q12.2 and encodes for the fat mass and obesity-associated protein that functions as a nucleic acid demethylase, thus removing methyl groups from DNA and RNA. The FTO protein forms part of the family Fe (II)- and 2-oxoglutarate-dependant dioxygenases.

Feb 8, 2025 · Fat mass and obesity associated gene, FTO, is associated with reduced brain volume in cognitively healthy subjects. The FTO gene is associated with the early onset of overweight in the Japanese population as well as in European populations. Three genotyped SNPs were in tight linkage disequilibrium.