Inhibition of CDK4/6 Overcomes Primary Resistance to PD-1 …
We identified a therapeutic target, CDK4/6, to overcome primary resistance to PD-1 blockade through comprehensive immunogenomic approaches. These data provide a rationale for …
CDK4: a master regulator of the cell cycle and its role in cancer
This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 …
Guanylate binding protein 4 shapes an inflamed tumor ... - Springer
Feb 12, 2024 · Pan-cancer analysis revealed that GBP4 plays a positive role in most cancer types via the majority of immunomodulators. Furthermore, GBP4 demonstrated positive associations …
Guanylate binding protein 4 shapes an inflamed tumor …
GBP4 expression was more highly upregulated in tumor tissues than in paracancerous tissues at the protein level (Fig. 5A, B; Supplementary Fig. S3A, B). Moreover, GBP4 was positively …
OSU Pathology - Vilgelm
Vilgelm AE*, Saleh N, Riemenschneider K, Slesur L, Chen S, Johnson C, Yang J, Shattuck-Brandt R, Yan C, Johnson D, Al-Rohil R, Halilovic E, Kauffmann R, Kelley M, Ayers G, Richmond A. " MDM2 antagonists overcome intrinsic …
GBP4 Gene - GeneCards | GBP4 Protein | GBP4 Antibody
Mar 30, 2025 · GBP4 (Guanylate Binding Protein 4) is a Protein Coding gene. Diseases associated with GBP4 include Patent Foramen Ovale. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and …
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Cyclin-dependent kinase 4 - Wikipedia
Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member of the cyclin-dependent kinase family, a group of serine/threonine kinases which regulate the cell cycle. CDK4 regulates the G1/S transition by contributing to the phosphorylation of retinoblastoma (RB) protein, which leads to the release of p…
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GBP4 is an immune-related biomarker for patients with …
Aug 4, 2022 · Guanylate Binding Protein 4 (GBP4) regulates innate immune response via interferon-gamma. GO annotations revealed that GBP4 regulates several biological processes, including GTP binding and GTP ase activity.
Pathology Outlines - CDK4
1 day ago · Use MDM2 and CDK4 coexpression to help diagnose low grade osteosarcomas and high grade osteosarcomas that progressed from low grade osteosarcomas (Am J Surg Pathol …
Distinct prognostic value of mRNA expression of guanylate …
A high expression of GBP1, GBP2, GBP3, GBP4 and GBP5 were correlated with favorable overall survival (OS) in the SKCM patients followed for over 30 years. In addition, a high expression of …
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