Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics. In many cell types, such as endothelial cells and monocytes, GBP1 expression ...

Mar 30, 2025 · GBP1 (Guanylate Binding Protein 1) is a Protein Coding gene. Diseases associated with GBP1 include Ulceroglandular Tularemia and Immune Deficiency Disease. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in Immune system.

GBP1 was found to restrict vesicular stomatitis, encephalomyocarditis, and hepatitis C viruses in IFN-γ– or IFN-α–treated HeLa cells and GBP1 overexpressing Huh 7 hepatocytes (Anderson et al., 1999; Itsui et al., 2009).

Jan 24, 2024 · Our results reveal a sophisticated activation mechanism for GBP1, in which nucleotide-dependent structural changes coordinate dimerization, oligomerization, and membrane binding to allow encapsulation of pathogens within an antimicrobial protein coat.

Jun 3, 2019 · GBP 1 targets Toxoplasma and Salmonella in macrophages and regulates host cell death. GBP 1 promotes Toxoplasma DNA detection by AIM 2‐ ASC ‐caspase‐8 leading to apoptosis and targeting of Salmonella by caspase‐4 leading to pyroptosis.

Here, we demonstrate that human guanylate-binding protein 1 (hGBP1) is a key protective factor against Toxoplasma gondii infection in human MSCs (hMSCs). The recruitment of hGBP1 to the parasitophorous vacuole membrane in IFN-γ–stimulated …

Jun 24, 2020 · Our findings indicate that in human epithelial cells GBP1 acts as a cytosolic LPS sensor and assembles a platform for caspase-4 recruitment and activation at LPS-containing …

Jun 15, 2020 · Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the...

Our results identify human GBP1 as the principal repetitive unit, numbering thousands of proteins per bacillus, that undergoes dramatic conformational opening to establish a host defense platform directly on the surface of gram-negative bacteria.

Jun 13, 2012 · Through the use of complementary GBP-1 overexpression and small interfering RNA-mediated knockdown studies, we now show that GBP-1 acts to inhibit pro-mitogenic β-catenin/T cell factor (TCF)...