Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene. [3][4] It belongs to the dynamin superfamily of large GTPases.

Mar 30, 2025 · Complete information for GBP1 gene (Protein Coding), Guanylate Binding Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

GBP1, the most widely studied GBP, has been studied for its antimicrobial properties. It can effectively polymerize and target the lipopolysaccharide cell wall of gram-negative bacteria.

Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics. In many cell types, such as endothelial cells and monocytes, GBP1 expression ...

Jul 1, 2019 · GBP1 thus acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes. Our findings expand the immune roles of human GBPs in regulating not only pyroptosis, but also apoptosis.

Feb 22, 2022 · GBP1 identifies gram-negative bacteria such as the enteric pathogen, Salmonella enterica serovar Typhimurium, that enter the cytoplasm of the host cell. GBP1 then quickly connects to LPS and stimulates the assembly of more …

Aug 16, 2020 · Guanylate binding protein 1 (GBP-1) promotes cell motility and invasiveness of lung adenocarcinoma. Yamakita I, et al. Biochem Biophys Res Commun, 2019 Oct 15. PMID 31421831. What's a GeneRIF? Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry.

Proteomics analysis of the tumor cells revealed Guanylate-Binding Protein 1 (GBP1) as a key T lymphocyte-induced protein that enables breast cancer cells to cross the blood-brain barrier (BBB). The GBP1 gene appeared to be up-regulated in breast cancer of patients who developed brain metastasis.

Jan 24, 2024 · The dynamin-related human guanylate-binding protein 1 (GBP1) mediates host defenses against microbial pathogens. Upon GTP binding and hydrolysis, auto-inhibited GBP1 monomers dimerize and assemble into soluble and membrane-bound oligomers, which are crucial for innate immune responses.

Jun 30, 2022 · GBP1 is a 65-kD GTPase protein in the GBP family that plays a crucial role in innate immunity 14, comprising a conserved region with an N-terminal globular GTPase domain and a C-terminal...