Apr 1, 2024 · Variant GNAQ and GNA11 cells had significantly increased NFAT-driven luciferase signal compared with WT, in the absence of extracellular calcium (Figure 1 c), confirming …

Using two cellular models, we find that disease-causing / variants hyperactivate GNAQ 11 constitutive and G-protein coupled receptor ligandeinduced intracellular calcium signaling in …

Jun 24, 2011 · By combining heterologous factors (melanopsin) and control modules (P NFAT) with promiscuous complementary endogenous machineries (G proteins, NFAT pathway), we …

Here, we examined the functional involvement of heterotrimeric G-proteins in TCR-induced immune responses. TCR/CD3 crosslinking resulted in activation of both Gaq and Gas, but not …

NFAT was described as an important regulator of genes involved in the control of the cell cycle and cell death, such as those for p21 WAF1/Cip1, cyclin-dependend kinase 4, c-myc, cyclin …

May 3, 1996 · This study establishes that NFAT transcription factors can serve as downstream effectors for G q-protein-coupled receptors that activate PLC and that such receptors can …

NFAT refers to a family of transcription activators that participate in the development of important vertebratespecific functions like immune and vascular system regulators (Graef et al., 2001b), …

May 3, 1996 · In PC12 cells expressing a Gi-coupled m2 muscarinic receptor, carbachol induces NFAT-mediated luciferase activity that is strictly dependent upon co-expression of a chimeric …

Effector proteins produce second messengers (e.g., cAMP) that subsequently activate transcription factors such as CRE, NFAT and SRF.

Jun 1, 1996 · Carbachol induces robust luciferase responses in Jurkat and pheochromocytoma PC12 cells expressing an NFAT-luciferase reporter construct and a Gq-coupled m3 muscarinic …