N-Acetylgalactosamine (GalNAc), is an amino sugar derivative of galactose. In humans it is the terminal carbohydrate forming the antigen of blood group A. [1] It is typically the first …

GalNAc-siRNA conjugates are a simple solution to the siRNA delivery problem for liver hepatocytes and have shown the RNAi (and antisense oligonucleotide) field the path forward …

Aug 5, 2020 · Targeted delivery of oligonucleotides to liver hepatocytes using N-acetylgalactosamine (GalNAc) conjugates that bind to the asialoglycoprotein receptor has …

GalNAc conjugates – GalNAc, or N-acetylgalactosamine, is a sugar molecule that can recognize and bind to a cell surface protein, the asialoglycoprotein receptor (ASGPR), which is …

N-acetylgalactosamine (GalNAc) is a well-defined liver-targeted moiety benefiting from its high affinity with asialoglycoprotein receptor (ASGPR).

Mar 31, 2025 · Solbinsiran, a GalNAc-conjugated small interfering RNA targeting hepatic angiopoietin-like protein 3 (ANGPTL3), reduced triglycerides and LDL-C concentrations in a …

Oct 14, 2021 · Concept of N-acetyl galactosamine (GalNAc)-aided delivery of siRNA drugs to the hepatocyte. Triantennary GalNAc-siRNA conjugates are recognized with high affinity by the …

Aug 5, 2020 · Targeted delivery of oligonucleotides to liver hepatocytes using N-acetylgalactosamine (GalNAc) conjugates that bind to the asialoglycoprotein receptor has …

N-acetyl-D-galactosamine is the D-enantiomer of N-acetylgalactosamine. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a N-acetyl-D …

Aug 17, 2023 · As most of the current siRNA products are conjugated by N -acetylgalactosamine (GalNAc), this review focuses on the PK/PD relationships and clinical pharmacology of …