
GAB2 - Wikipedia
GAB2 is a docking protein with a conserved, folded PH domain attached to the membrane and a large disordered region, which hosts interactions with signaling molecules. It is a member of the GAB/DOS family localized on the internal membrane of the cell.
GAB2 Gene - GeneCards | GAB2 Protein | GAB2 Antibody
Mar 30, 2025 · GAB2 (GRB2 Associated Binding Protein 2) is a Protein Coding gene. Diseases associated with GAB2 include Noonan Syndrome-Like Disorder With Loose Anagen Hair 1 and Childhood Angiosarcoma. Among its related pathways are Insulin receptor signalling cascade and FLT3 signaling in disease.
Structure and function of Gab2 and its role in cancer (Review)
Gab2, a key member of the Gab family of proteins, is involved in the amplification and integration of signal transduction, evoked by a variety of extracellular stimuli, including growth factors, cytokines and antigen receptors.
Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in …
Apr 8, 2021 · Gab2 (Grb2-associated binder2) silencing or deficiency inhibits TNFα (tumor necrosis factor alpha)-induced, IL (interleukin)-1β–induced, or lipopolysaccharide (LPS)-induced proinflammatory responses in endothelial cells.
GAB2 GRB2 associated binding protein 2 [ (human)] - National …
GAB2 is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer.
Gab2 deficiency suppresses high-fat diet-induced obesity by …
Feb 26, 2021 · Our research suggests that deletion of Gab2 suppresses diet-induced obesity by multiple pathways and Gab2 may be a novel therapeutic target for the treatment of obesity and associated...
Gab2 growth factor receptor bound protein 2-associated protein …
Feb 8, 2025 · Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor-associated macrophages. The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis. Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in vitro and in vivo study.
Understanding the Mechanism of Recognition of Gab2 by the N …
Jun 11, 2020 · Gab2 is a scaffold protein that is structurally composed by a Pleckstrin Homology (PH) domain, that anchors the protein to the plasma membrane of the cell, and a C-terminal long disordered region presenting several binding sites for signaling proteins [14,15].
GAB2--a scaffolding protein in cancer - PubMed
GAB2 is essential for two major signal transduction pathways in cancer, the PI3-K-AKT and extracellular signal-regulated kinase (ERK) signaling pathways, and thus regulates a number of key cellular processes.
Gab2 is a novel prognostic factor for colorectal cancer patients
Mar 1, 2015 · Gab2 (Grb2-associated binder 2), a member of the DOS/Gab family of scaffolding adapters, serves as a critical signal amplifier downstream of various growth factor receptors. Recent studies have identified that Gab2 is overexpressed in several cancer types and that increased Gab2 expression promotes …