Jul 14, 2022 · Glycogen synthase (GYS1) is the central enzyme in muscle glycogen biosynthesis. GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by...

Jan 17, 2024 · Here, we report the preclinical characterization of MZ-101, a small molecule that potently inhibits GYS1 in vitro and in vivo without inhibiting GYS2, a related isoform essential for synthesizing liver glycogen. Chronic treatment with MZ-101 depleted muscle glycogen and was well tolerated in mice.

Jun 11, 2022 · We describe the 2.6 Å resolution cryo-EM structure of phosphorylated human GS revealing an autoinhibited GS tetramer flanked by two GN dimers. Phosphorylated N- and C-termini from two GS...

Mar 30, 2025 · GYS2 (Glycogen Synthase 2) is a Protein Coding gene. Diseases associated with GYS2 include Glycogen Storage Disease 0, Liver and Glycogen Storage Disorder Due To Hepatic Glycogen Synthase Deficiency. Among its related pathways are Activation of cAMP-Dependent PKA and Glycogen metabolism.

Apr 1, 2012 · Recombinant muscle GYS1 (glycogen synthase 1) and recombinant liver GYS2 were phosphorylated by recombinant AMPK (AMP-activated protein kinase) in a time-dependent manner and to a similar stoichiometry.

Jul 5, 2022 · In muscle, glycogen synthesis is initiated by the enzymes glycogenin-1 (GYG1), which seeds the molecule by autoglucosylation, and glycogen synthase-1 (GYS1), which extends the glycogen chain. Although both enzymes are required for proper glycogen production, the nature of their interaction has been enigmatic.

Mar 30, 2025 · GYS1 (Glycogen Synthase 1) is a Protein Coding gene. Diseases associated with GYS1 include Glycogen Storage Disease 0, Muscle and Glycogen Storage Disease Due To Muscle And Heart Glycogen Synthase Deficiency. Among its related pathways are Activation of cAMP-Dependent PKA and Glycogen metabolism.

Oct 1, 1998 · Two isozymes of synthase, a skeletal muscle type (GYS1; 138570) and a liver type (GYS2), have been identified in rabbit and rat tissues using specific polyclonal antibodies. The skeletal muscle type isozyme is present in several organs in addition to skeletal muscle; the liver isozyme has been identified only in liver.

The results show that either of the three enzymes (GYS1, GYS2, GBE1) that control the glycogen synthesis reaction are upregulated in 18% of AML patients and that the patient population associated with increased enzyme levels showed significantly shorter survival.

May 9, 2014 · Liver glycogen synthase is distinct (see GYS2, 138571). By Southern blot analysis of somatic cell hybrid DNAs, Groop et al. (1993) determined that the GYS1 gene is located on chromosome 19. Lehto et al. (1993) regionalized the GYS gene to …