Mar 30, 2025 · GYS1 (Glycogen Synthase 1) is a Protein Coding gene. Diseases associated with GYS1 include Glycogen Storage Disease 0, Muscle and Glycogen Storage Disease Due To Muscle And Heart Glycogen Synthase Deficiency. Among its related pathways are Activation of cAMP-Dependent PKA and Glycogen metabolism.

Jul 14, 2022 · GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by allosteric activation of glucose-6-phosphate (Glc6P).

The GYS1 gene provides instructions for making an enzyme called muscle glycogen synthase. Muscle glycogen synthase is produced in most cells but is most abundant in heart (cardiac) muscle and muscles used for movement (skeletal muscles).

Jan 17, 2024 · Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays a central role in energy homeostasis and has been proposed as a therapeutic target in multiple glycogen stor...

Jul 14, 2020 · Silencing of GYS1 induced metabolomic perturbation manifested by a carbohydrate metabolism shift. Overexpression of GYS1 promoted tumor growth whereas its silencing suppressed it by activating the canonical NF-κB pathway.

GYS1 regulation by HIF plays a central role in the hypoxic accumulation of glycogen, and hypoxia also upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-alpha glucan branching enzyme (GBE1)

The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex. Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome.

Jan 4, 2025 · Clinical resource with information about GYS1, Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men., Glycogen storage disease due to muscle and heart glycogen synthase deficiency, and available tests.

Jul 5, 2022 · To better understand the structural mechanism of GYS1 activation and the effect it has on the GYG1 dimer, we prepared GYS1-Cryo:GYG1-Y195F in the presence of G6P and determined the structure of the complex at 3.4 Å resolution by …

May 9, 2014 · R309 is conserved in human GYS1 and lies in a region that shares extensive identity with human GYS1. Functional analysis demonstrated elevated glycogen synthase activity in PSSM horses, indicating that R309H is a gain-of-function mutation.