GSK-3β S9A overexpression leads murine hippocampal neural
To this end, we stereotaxically injected a GSK-3β S9A-encoding retrovirus (GSK-3β-V5) into the DG of young adult C57BL6/J Ola Hsd female mice and studied the cell lineage acquisition, …
- Author: Miguel Flor-García, Miguel Flor-García, Jesús Ávila, María Llorens-Martín
- Publish Year: 2021
See results only from pubmed.ncbi.nlm.nih.govAn expanding GSK3 network: implications for aging research
Beta cell-specific expression of a constitutively active GSK3b transgene (GSK3b S9A) resulted in a reduction in beta cell mass and function (Liu e…
GSK-3β dysregulation contributes to parkinson’s-like
Nov 14, 2014 · GSK-3 β -S9A is capable of activation through endogenous natural signaling events, yet is unable to become inactivated through …
- Author: J. J. Credle, J. L. George, J. Wills, V. Duka, K. Shah, Y. C. Lee, O. Rodriguez, T. Simkins, M. Wint...
- Estimated Reading Time: 11 mins
- Publish Year: 2015
GSK-3β dysregulation contributes to parkinson's-like …
GSK-3 β -S9A is capable of activation through endogenous natural signaling events, yet is unable to become inactivated through phosphorylation at serine-9. We used behavioral, biochemical, …
In vivo regulation of glycogen synthase kinase 3β activity in …
Aug 17, 2017 · Glycogen synthase kinase 3β (GSK3β) is a multifunctional protein kinase involved in many cellular activities including development, differentiation and diseases. GSK3β is …
GSK3β regulates AKT-induced central nervous system …
Mar 14, 2016 · Expression of GSK3β S9A, a kinase active mutant of GSK3β, significantly reduced axon regeneration induced by AKT activation. Deletion of …
- Author: Xinzheng Guo, William D Snider, Bo Chen
- Publish Year: 2016
Inhibitory phosphorylation of GSK-3β by AKT, PKA, and …
To examine that possibility, we transfected GSK-3β-null cells with empty vector, wild-type GSK-3β-HA, or GSK-3β-S9A-HA (S9A-HA). Overexpression of GSK-3β-HA reduces NFAT5 transcriptional activity relative to empty vector ( Fig. 4 B ).
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GSK3β Regulates Brain Energy Metabolism - Cell Press
May 15, 2018 · Genetic approaches confirm the role of GSK3β in cellular metabolic regulation, where lithium’s effects were diminished when levels of …
- Author: Stephen A. Martin, Dylan C. Souder, Karl N. Miller, Josef P. Clark, Abdul Kader Sagar, Kevin W. Elic...
- Publish Year: 2018
An expanding GSK3 network: implications for aging research
Jul 17, 2019 · Beta cell-specific expression of a constitutively active GSK3b transgene (GSK3b S9A) resulted in a reduction in beta cell mass and function (Liu et al. 2008). Conversely, …
GSK‐3β S9A overexpression leads murine ... - Wiley Online Library
May 6, 2021 · Indeed, GSK-3β S9A overexpression not only prevented neuronal cell fate determination but also modified the classical morphological development and migratory …
Overexpression of GSK3b S9A resulted in tau …
By analyzing the offspring from several transgenic mouse lines, including lines other than 3083 and 3107, it was found that overexpressed constitutively active human GSK3b S9A resulted in …
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