PI3K/Akt-dependent phosphorylation of GSK3β and activation of …
Pharmaceutical inhibition of PI3K with LY294002 or Akt siRNA significantly decreased Wnt5a-induced GSK3β phosphorylation and consequently cell migration. Additionally, GSK3β siRNA …
- Author: Jiaojing Liu, Yujie Zhang, Rui Xu, Jun Du, Zhenzhen Hu, Ling Yang, Yongchang Chen, Yichao Zhu, Luo G...
- Publish Year: 2013
See results only from pubmed.ncbi.nlm.nih.govWnt3A Induces GSK-3β Phosphorylation and β-Catenin ... - PubM…
Here, we revealed that Wnt3A induces not only the phosphorylation of GSK-3β and accumulation of β-catenin but also RhoA activation in RAW…
Inhibition of glycogen synthase kinase 3 by lithium, a mechanism …
Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of lithium ions on mood regulation in bipolar disorder and other mental illnesses, including major …
Identification of transcriptional targets of GSK3 involved in ...
Jan 31, 2018 · We have identified an invasion signature downstream of GSK3b, which includes activators and inactivators of the Rho family of small GTPases. Knockdown of the Rac1 …
- Author: Anke Bruning-Richardson, Alastair Droop, Daniel Tams, Marjorie Boissinot, Josie Hayes, Vinton Cheng,...
- Publish Year: 2018
Wnt3A Induces GSK-3β Phosphorylation and β-Catenin ... - PubMed
Here, we revealed that Wnt3A induces not only the phosphorylation of GSK-3β and accumulation of β-catenin but also RhoA activation in RAW264.7 and HEK293 cells. Notably, sh-RhoA and …
RhoA/ROCK/GSK3β Signaling: A Keystone in Understanding
Feb 14, 2025 · Emerging evidence suggests that RhoA, Rho-associated coiled-coil kinase (ROCK), and their downstream effector molecule glycogen synthase 3β (GSK3β) interact …
ROCK2 promotes HCC proliferation by CEBPD inhibition through …
Apr 13, 2015 · Mechanistically, we found that Rock2 regulates CEBPD expression through the p-GSK3β/β-catenin pathway. Taken together, we identified a novel Rock2-p-GSK3β/β-catenin …
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GSK3B glycogen synthase kinase 3 beta [ Homo sapiens (human) ]
Feb 9, 2025 · It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. …
(PDF) Wnt3A Induces GSK-3β Phosphorylation and β
Aug 30, 2016 · Here, we revealed that Wnt3A induces not only the phosphorylation of GSK-3β and accumulation of β-catenin but also RhoA activation in RAW264.7 and HEK293 cells. Notably, sh-RhoA and Tat-C3...
Glycogen synthase kinase-3 beta - DrugBank Online
Feb 7, 2011 · Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and …
Glycogen Synthase Kinase 3 Beta (GSK3β) at the Tip of ... - Springer
Oct 25, 2013 · In this review, we summarize current understanding of the role of GSK3β during neuronal development and regeneration. In particular, we discuss GSK3β activity levels and …
