May 14, 2022 · Here, we found that eIF4E2, a hypoxia-activated translation initiation factor, interacted with GSK3β to maintain phosphorylation of p53, thus resisting senescence under …

Dec 5, 2003 · This regulatory role of GSK3beta was demonstrated by large reductions of p53-induced increases in the levels of MDM2, p21, and Bax when GSK3beta was inhibited. …

GSK-3β was shown to directly phosphorylate p53 at Ser-33 and to mediate p53 phosphorylation at Ser-315 and Ser-376 [48, 49]. GSK-3 β also promotes p53-mediated transcription of …

GSK3β promotes apoptosis in conditions of hypoxia and DNA damage by inhibiting cell survival signals like cAMP-response element binding (CREB) protein and heat-shock protein 1 and …

We show that glycogen synthase kinase 3 (GSK-3) phosphorylated the Mdm2 protein in vitro and in vivo in the central domain. Inhibition of GSK-3 rescued p53 from degradation in an Mdm2 …

GSK3beta can regulate p53's transcriptional activity by phosphorylating serine 33. However, GSK3beta does not appear to be part of the p53-DNA damage response pathway. Instead, …

Recent evidence suggests that glycogen synthase kinase-3β (GSK3β) is implicated in both sporadic and familial forms of Alzheimer's disease. The transcription factor, p53 also plays a …

The recent discovery of direct interactions between two important regulators of cell fate, the tumor suppressor p53 and glycogen synthase kinase-3β (GSK3β), led us to examine the mechanism …

Mar 5, 2009 · In this study we identified the GSK3β N-terminal amino acids 78–92 as necessary for its association with p53. Inhibitors of GSK3 impaired the acetylation of p53 at Lys373 and …

In the present study, we showed that GSK3b regulates p53 through a novel mechanism; i.e., GSK3b controls p53 mRNA translation via phosphorylation of RNPC1. We also provided …