GSK3B EMT - Search

About 19,900 results

Open links in new tab

PubMed
https://pubmed.ncbi.nlm.nih.gov
GSK3β controls epithelial-mesenchymal transition and tumor
Jun 12, 2014 · Glycogen synthase kinase 3 beta (GSK3β) is highly inactivated in epithelial cancers and is known to inhibit tumor migration and invasion. The zinc-finger-containing …
- Author: Shih-Han Kao, Wen-Lung Wang, Chi-Yuan Chen, Yih-Leong Chang, Yi-Ying Wu, Yi-Ting Wang, Shu-Ping Wang...
- Publish Year: 2014
Other content from pubmed.ncbi.nlm.nih.gov
See more
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
GSK3β regulates epithelial-mesenchymal transition and cancer …
We identified a GSK3β inhibitor, BIO, in a drug screen as one of the most potent inhibitors of EMT. BIO and two other GSK3β inhibitors, TWS119 and LiCl, also decreased the expression …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Glycogen Synthase Kinase 3β in Cancer Biology and Treatment
GSK3β is a crucial member of the Wnt/β-catenin-, hedgehog (Hh)-, notch- and c-myc-mediated major pro-oncogenic pathways, while also being a negative regulator of …
Studies of GSK3B EMT
National Center for Biotechnology Information
Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 pathways elicit essential regulatory influences on cancer initiation, EMT and prog...
Author: James A. McC…
Published: 2017/02/02
Publication: Oncotarg…
PubMed
GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer
Background: Triple-negative breast cancers (TNBCs), which lack receptors for estrogen, progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive. Consequently, patients diagnosed with TNBCs have reduced overall and disease-free survival rates compared to patients w...
Author: Geraldine Vidh…
Published: 2019/03/07
Keywords: Triple-nega…
National Center for Biotechnology Information
An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice
PDAC (aka pancreatic cancer) is a disease with no effective treatment and with one of the lowest survival rates of any cancer. One of the major reasons for such a poor outcome is the simultaneous activation of multiple pro-cancer pathways in the cancer cells which allows them to overcome treatments ...
Author: Mouad Edderk…
Published: 2018/12
DOI: 10.1053/j.gastro.2…
PubMed
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
The phenotypic changes of increased motility and invasiveness of cancer cells are reminiscent of the epithelial-mesenchymal transition (EMT) that occurs during embryonic development. Snail, a zinc-finger transcription factor, triggers this process by repressing E-cadherin expression; however, the me...
Author: Binhua P Zhou
Published: 2004/10
Keywords: National In…
PubMed
PI3K/Akt/GSK-3β signal pathway is involved in P2X7 receptor-induced proliferation and EMT of colorectal cancer cells
P2X7 receptor (P2X7R) plays an important role in regulating the growth of tumor cells. However, the role of P2X7R in colorectal cancer (CRC) has remained poorly understood. Therefore, in this study, in vivo and in vitro experiments were performed to investigate the effect of P2X7R on the proliferati...
Author: Wen-Jun Zhang
Published: 2021/05/15
Keywords: Colorectal …
Nature
https://www.nature.com › articles
PIM1 kinase promotes EMT-associated osimertinib resistance via
Sep 3, 2024 · We identify upregulation of the proviral integration site for Moloney murine leukemia virus 1 (PIM1) and functional inactivation of glycogen synthase kinase 3β (GSK3β) as drivers of...
- Author: Jing Zhou
PubMed
https://pubmed.ncbi.nlm.nih.gov
GSK3β regulates epithelial-mesenchymal transition and cancer
Mar 7, 2019 · Results: We identified a GSK3β inhibitor, BIO, in a drug screen as one of the most potent inhibitors of EMT. BIO and two other GSK3β inhibitors, TWS119 and LiCl, also …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Roles of GSK-3 and microRNAs on epithelial mesenchymal …
Feb 2, 2017 · Introduction of an activated GSK3B gene into RCC cells inhibited TNF-alpha-induced anchorage-independent growth as well as tumorigenicity in mice. In contrast, …
- Author: James A. McCubrey, Timothy L. Fitzgerald, Li V. Yang, Kvin Lertpiriyapong, Linda S. Steelman, Stephe...
- DOI: 10.18632/oncotarget.13991
- Publish Year: 2017
- Publication: Oncotarget. 2017 Feb 21; 8(8): 14221-14250.
People also ask
Which GSK3 inhibitor is the most potent inhibitor of EMT?
Results: We identified a GSK3β inhibitor, BIO, in a drug screen as one of the most potent inhibitors of EMT. BIO and two other GSK3β inhibitors, TWS119 and LiCl, also decreased the expression of mesenchymal markers in several different cell lines with a mesenchymal phenotype.
GSK3β regulates epithelial-mesenchymal transition and cancer ... - Pub…
pubmed.ncbi.nlm.nih.gov
What is GSK3 in cancer treatment?
Future Perspectives on GSK3β in Cancer Treatment 7. Conclusions Glycogen synthase kinase (GSK)3β is a multifunctional serine/threonine protein kinase with more than 100 substrates and interacting molecules. GSK3β is normally active in cells and negative regulation of GSK3β activity via phosphorylation of its ...
Glycogen Synthase Kinase 3β in Cancer Biology and Treatment
pmc.ncbi.nlm.nih.gov
How does GSK-3 regulate tumor migration and invasion?
GSK-3β is known to regulate tumor migration and invasion through control of EMT. Signaling pathways that inactivate GSK-3β, such as phosphatidylinositol 3 kinase/Akt and mitogen-activated protein kinase, may promote the cell cycle, anti-apoptosis, and invasion, thus facilitating tumor progression [ 52, 53, 54, 55 ].
GSK-3β regulates the endothelial-to-mesenchymal transition via
jeccr.biomedcentral.com
Which cell type is expressing/activating GSK-3 in MCTs?
Signaling pathways that inactivate GSK-3β, such as phosphatidylinositol 3 kinase/Akt and mitogen-activated protein kinase, may promote the cell cycle, anti-apoptosis, and invasion, thus facilitating tumor progression [ 52, 53, 54, 55 ]. However, our data is not discern which cell type is expressing/activates GSK-3β in MCTSs.
GSK-3β regulates the endothelial-to-mesenchymal transition via
jeccr.biomedcentral.com
What is GSK3 kinase?
Glycogen synthase kinase (GSK)3β is an isoform of the GSK3 family of kinases. It regulates many fundamental biological processes in cells by phosphorylating serine and threonine residues and thus interacting with more than 100 functional and structural proteins [1, 2, 3, 4].
Glycogen Synthase Kinase 3β in Cancer Biology and Treatment
pmc.ncbi.nlm.nih.gov
How does GSK-3 regulate endothelial-to-mesenchymal transition in multicellular tumor spheroid?
Kim, SH., Song, Y. & Seo, H.R. GSK-3β regulates the endothelial-to-mesenchymal transition via reciprocal crosstalk between NSCLC cells and HUVECs in multicellular tumor spheroid models.
GSK-3β regulates the endothelial-to-mesenchymal transition via
jeccr.biomedcentral.com
Feedback
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
The role of glycogen synthase kinase 3 (GSK3) in cancer with …
In response to transforming growth factor beta (TGF-β), ERK kinase inactivates GSK3β, resulting in Snail protein accumulation [45,46] and promotion of epithelial-mesenchymal transition …
Journal of Experimental & Clinical Cancer Research
https://jeccr.biomedcentral.com › articles
GSK-3β regulates the endothelial-to-mesenchymal transition via ...
Secretomes from NSCLC Spheroids Induced EndMT
Co-culture with NSCLC Cells and HUVEC Cells to Evaluate Chemoresistance in MCTS
CHIR-99021 Enhances The Efficiency of Anticancer Therapies in Vivo
To ascertain our hypothesis, we sought to confirm whether secretomes from different culture systems of lung cancer cells affected on EndMT of HUVEC cells have collected conditioned medium(CM) from monolayer (2D) cultured H460 cells or 3D cultured H460 cells. 2D cultured HUVEC cells were incubated with CMs from monolayer cultured H460 cells or 3D cu...
See more on jeccr.biomedcentral.com
- Author: Se-Hyuk Kim, Yeonhwa Song, Haeng Ran Seo
- Published: Feb 1, 2019
- Publish Year: 2019
DigitalCommons@TMC
https://digitalcommons.library.tmc.edu › utgsbs_dissertations
"Gsk3B Regulates Epithelial-Mesenchymal Transition And Cancer …
Oct 24, 2017 · Taken together, our studies demonstrate that GSK3β is a novel target for TNBCs and suggest that the GSK3β inhibitors could serve as selective inhibitors of EMT and CSC …
nih.gov
https://pubmed.ncbi.nlm.nih.gov
Dual regulation of Snail by GSK-3beta-mediated phosphorylation …
We show that GSK-3beta binds to and phosphorylates Snail at two consensus motifs to dually regulate the function of this protein. Phosphorylation of the first motif regulates its beta-Trcp …
Pagination
- 1
- 2
- 3
- 4
- Next