GSK3 has been shown to phosphorylate several upstream and downstream components of the PI3K/AKT/mTOR signalling network, including AKT itself, RICTOR, TSC1 and 2, PTEN and IRS1 and 2, with the potential to apply feedback control within the network.

Nov 27, 2021 · GSK3α has also been shown to regulate Akt in a manner unique from GSK3β, as GSK3α has been reported to promote the activating phosphorylation of Akt, which may be a cell type specific mechanism for GSK3α to attenuate its own actions (Lu et al., 2011).

Aug 17, 2017 · Glycogen synthase kinase 3β (GSK3β) is a multifunctional protein kinase involved in many cellular activities including development, differentiation and diseases. GSK3β is thought to be...

Less attention has been paid to the role of glycogen synthase kinase 3 β (GSK3β), a target of AKT. AKT is a serine/threonine kinase activated by a dual regulatory mechanism that requires translocation to the plasma membrane and phosphorylation.

Oct 20, 2016 · Importantly, we demonstrated by pharmacological inhibition and siRNA knockdown that GSK3β signaling is responsible, at least in part, of the apoptosis triggered by AKT inhibition. Moreover, GSK3β...

Aug 1, 2017 · GSK3 has been shown to phosphorylate several upstream and downstream components of the PI3K/AKT/mTOR signalling network, including AKT itself, RICTOR, TSC1 and 2, PTEN and IRS1 and 2, with the potential to apply feedback control within the network.

Apr 1, 2013 · High NaCl activates the transcription factor nuclear factor of activated T cells 5 (NFAT5), leading to increased transcription of osmoprotective target genes. Kinases PKA, PI3K, AKT1, and p38α were known to contribute to the high NaCl-induced increase of NFAT5 activity.

Much less attention has been paid to the role of glycogen synthase kinase 3 β (GSK3β), a target of AKT. In this review we focus on the function of AKT/GSK3β signaling in GBM. Keywords: AKT; GSK3β; Glioblastoma; Therapeutic target. Glioblastoma (GBM) …

In mammals GSK3 exists in two forms, GSK3a and GSK3b, paralogs which share a highly conserved catalytic domain but differ at both termini and are encoded by separate genes, in humans named GSK3A and GSK3B.

Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. [5] [6] In mice, the enzyme is encoded by the Gsk3b gene. [7] Abnormal regulation and expression of GSK-3 beta is associated with an …