Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. [5] [6] In mice, the enzyme is encoded by the Gsk3b gene. [7] Abnormal regulation and expression of GSK-3 beta is associated with an …

Mar 30, 2025 · GSK3B (Glycogen Synthase Kinase 3 Beta) is a Protein Coding gene. Diseases associated with GSK3B include Cardiomyopathy, Familial Hypertrophic, 1 and Hematologic Cancer. Among its related pathways are Signaling by …

Nov 27, 2021 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility?

GSK-3β is essential for the control of glucose metabolism, signal transduction, and tissue homeostasis. As more than 100 known proteins have been identified as GSK-3β substrates, it is sometimes referred to as a moonlighting kinase. Previous studies have elucidated the regulation modes of GSK-3β.

Glycogen synthase kinase (GSK)3β is an isoform of the GSK3 family of kinases. It regulates many fundamental biological processes in cells by phosphorylating serine and threonine residues and thus interacting with more than 100 functional and structural proteins [1, 2, 3, 4].

Glycogen Synthase Kinase 3 (GSK3) is one of the Serine/Threonine protein kinases, which has gained a lot of attention for its role in a variety of pathways. It has two isoforms, GSK3α and GSK3β. However, GSK3β is highly expressed in different areas of the brain and has been implicated in Alzheimer's disease as it is involved in tau phosphorylation.

GSK3B encodes a multifunctional serine-threonine kinase of the glycogen synthase kinase subfamily. It acts as a negative regulator of the hormonal control of glucose homeostasis by phosphorylating glycogen synthases.

Aug 17, 2017 · Glycogen synthase kinase 3β (GSK3β) is a multifunctional protein kinase that targets Ser/Thr residues with a priming phosphorylation at the fourth amino acid on the C-terminal side 1, 2....

Feb 9, 2025 · It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

Apr 16, 2012 · Precisely how GSK3b maintains its pathway specificity efficiently at the crossroads of many cellular processes is still unclear. Many inhibitors of GSK3b exist, however these compounds have been found lacking in selectivity, with …