Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues.

Nov 27, 2021 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

In this review we present an overview of the various processes in which GSK-3 plays a key role and describe the current status of knowledge of GSK-3 regulation. There are two mammalian …

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded in mammals by two genes that generate two related …

Aug 1, 2017 · GSK3 was one of the first identified substrates of the heavily studied oncogenic kinase AKT, phosphorylation by which inhibits GSK3 activity via the formation of an …

Originally identified as a regulator of glycogen metabolism, GSK3 acts as a downstream regulatory switch for numerous signaling pathways, including cellular responses to WNT, …

Jan 2, 2015 · Signaling cascades regulated by glycogen synthase kinase-3 (GSK-3) in heart. In response to growth factor binding to their receptors, the phosphoinositide 3 kinase/AKT8 virus …

In this article, we provide an overview of how this dual function of components of the GPCR desensitization machinery relates to dopamine-receptor-mediated responses and we …

GSK-3 is one of the few signaling mediators that play central roles in a diverse range of signaling pathways, including those activated by Wnt, PI3K, growth factors, cytokines, and ligands for G …

Nov 15, 2011 · Sgg (GSK-3) phosphorylates Timeless and regulates nuclear translocation of the Period/Timeless heterodimer (Martinek et al., 2001). GSK-3 has also been demonstrated to …