Jan 1, 2006 · Glycogen-synthase kinase-3 (GSK-3) and extracellular signal-regulated kinase (ERK) are critical downstream signaling proteins for the PI3-kinase/Akt and Ras/Raf/MEK-1 pathway, respectively, and regulate diverse cellular processes including embryonic development, cell differentiation and apoptosis.

Jun 23, 2017 · Here, we show that extracellular signal–regulated kinases (ERK1/2) respond to insulin stimulation and integrate insulin signaling to phosphorylate and thus inactivate GSK3β, resulting in increased...

Nov 27, 2021 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility?

Jul 22, 2005 · Erk, which is activated by HBX, associates with GSK-3β through a docking motif (291 FKFP) of GSK-3β and phosphorylates GSK-3β at the 43 Thr residue, which primes GSK-3β for its subsequent phosphorylation at Ser9 by p90RSK, resulting in inactivation of GSK-3β and upregulation of β-catenin.

Mar 27, 2017 · The data presented here demonstrate that APP expression and neuronal exposure to oligomeric Aβ42 enhance Ras/ERK signaling cascade and glycogen synthase kinase 3 (GSK-3) activation.

In a distinct study, ubiquitination of GSK-3 at lysine 63 by the E3 ligase TNF receptor-associated factor 6 (TRAF6) was shown to be essential for incorporation of GSK-3 into a Toll-like receptor 3-assembled multiprotein complex that then activated an ERK and p38 MAPK immune response via pro-inflammatory cytokine production 33. Only GSK-3β (not ...

Jul 22, 2005 · Erk, which is activated by HBX, associates with GSK-3β through a docking motif (291FKFP) of GSK-3β and phosphorylates GSK-3β at the 43Thr residue, which primes GSK-3β for its subsequent phosphorylation at Ser9 by p90RSK, resulting in inactivation of GSK-3β and upregulation of β-catenin.

Jun 23, 2017 · Here, we show that extracellular signal–regulated kinases (ERK1/2) respond to insulin stimulation and integrate insulin signaling to phosphorylate and thus inactivate GSK3β, resulting in increased protein synthesis that is independent of Akt/mTORC1 activity.

Dec 31, 2023 · Glycogen Synthase Kinase-3 (GSK3), a complex serine/threonine kinase, has emerged as a key player with intricate roles in various cellular processes, including cell proliferation, differentiation, apoptosis, and metabolism.

Aberrant GSK-3 activity has been associated with many human diseases, including cancer, highlighting its potential therapeutic relevance as a target for anticancer therapy. Recently, newly emerging data have demonstrated the pivotal role of GSK-3 in the anticancer immune response.