GSK3 has been shown to phosphorylate several upstream and downstream components of the PI3K/AKT/mTOR signalling network, including AKT itself, RICTOR, TSC1 and 2, PTEN and IRS1 and 2, with the potential to apply feedback control within the network.

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues.

Nov 27, 2021 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility?

GSK-3 interacts with many signaling pathways. Critical pathways often dysregulated in cancer are the PI3K/PTEN/Akt/mTORC1 and Wnt/beta-catenin pathways. GSK-3 interacts with both Akt, TSC2 to regulate mTORC1. Akt has a negative effect on GSK-3 as when GSK-3 is phosphorylated by Akt, GSK-3 can not phosphorylate TSC2.

Aug 1, 2017 · GSK3 has been shown to phosphorylate several upstream and downstream components of the PI3K/AKT/mTOR signalling network, including AKT itself, RICTOR, TSC1 and 2, PTEN and IRS1 and 2, with the potential to apply feedback control within the network.

GSK-3 is a potential target in cancer due to its roles in various signaling pathways including the NF-κB protein which is often deregulated in cancer and can induce many pro-inflammatory genes which contribute to cancer progression. GSK-3 also plays prominent roles in the EGFR/PI3K/AKT/GSK-3/mTORC1, NF-κB and the WNT/β-catenin pathways.

Oct 20, 2016 · In this study we explored the molecular mechanisms involved in the regulation of PSC survival by AKT. We found that inhibition of AKT with three non-structurally related inhibitors (GSK690693,...

The Akt/GSK-3 signaling pathway is one of the critical signaling pathways dysregulated in numerous human cancers. The Akt cascade acts in the cancer process by regulating apoptosis, cell cycle, metabolism, and cells' longevity.

Sep 9, 2020 · Our study identified the AKT/GSK-3β/β-catenin axis as a critical mediator of EPO-induced glioma proliferation and further provided a clinically significant dimension to the biology of EPO. Erythropoietin (EPO) is an important stimulator of erythropoiesis in …

Apr 1, 2014 · GSK-3 is unique in its mode of substrate recognition and the regulation of its kinase activity, which is repressed by pro-survival phosphoinositide 3-kinase (PI3K)–AKT signaling. In turn, GSK-3 exhibits pro-apoptotic functions when the PI3K–AKT pathway is inactive.