Activators and Inhibitors of NRF2: A Review of Their Potential for ...
The phosphorylation of NRF2 by GSK-3 leads to its ubiquitination by the E3 ligase β-TrCP and subsequent proteasomal degradation. An aberrant activity of GSK-3 is linked with several …
GSK-3β downregulates Nrf2 in cultured cortical neurons and in …
Feb 3, 2016 · Glycogen synthase kinase 3β (GSK-3β) may play a critical role in regulating Nrf2 in a Kelch-like ECH-associated protein 1 (Keap1)-independent manner. However, the …
GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant ...
Sep 1, 2019 · GSK3β-mediated Keap1-independent regulation of Nrf2 is a novel therapeutic target for modifying long-term sequelae of AKI. Transition of acute kidney injury (AKI) to …
Regulation of GSK3β/Nrf2 signaling pathway modulated erastin …
Enhanced erastin-induced ferroptosis by overexpression of GSK-3β was blocked by activating Nrf2. We further confirmed that overexpression of GSK-3β strengthened erastin-induced tumor …
Pharmacological targeting of GSK-3 and NRF2 provides …
Nov 6, 2017 · In this study we demonstrate for the first time that pharmacological treatment with DMF, by disrupting the KEAP1/NRF2 interaction and through the GSK-3β/NRF2 signaling …
GSK-3β Acts Upstream of Fyn Kinase in Regulation of Nuclear …
We demonstrate that GSK-3β acts upstream of Fyn kinase in control of nuclear export of Nrf2. Chemical and short interfering RNA-mediated inhibition of GSK-3β led to nuclear accumulation …
Regulation of Nrf2 by phosphorylation: Consequences for biological ...
May 20, 2021 · GSK-3β inhibitors may reduce the hyperphosphorylation of tau directly while simultaneously inducing NRF2 activity to reduce oxidative stress and protect neurocytes. …
Regulation of GSK3β/Nrf2 signaling pathway modulated
Jul 8, 2020 · GSK-3β is a fundamental regulator in the modulation of the antioxidant cell defense elicited by the transcription factor Nrf2. We detected the GSK-3β and Nrf2 protein levels by …
Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway …
Jan 28, 2020 · In the present study, we determined whether farrerol can interact with glycogen synthase kinase 3 β - (GSK-3 β -) nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidant …
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its ...
Aug 8, 2013 · The ability of one of the two β-TrCP-binding sites to serve as a degron could be both increased and decreased by manipulation of glycogen synthase kinase-3 (GSK-3) …
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