Jan 1, 2025 · This study aims to explore the modulatory impact of gsk-3β (Glycogen synthase kinase-3β) on the intrinsic immunity against Aeromonas hydrophila in zebrafish, with the objective of uncovering a new avenue for enhancing fish antimicrobial activity through gene editing.

This study aims to explore the modulatory impact of gsk-3β (Glycogen synthase kinase-3β) on the intrinsic immunity against Aeromonas hydrophila in zebrafish, with the objective of uncovering a new avenue for enhancing fish antimicrobial activity through gene editing.

Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded in mammals by two genes that generate two related proteins: GSK-3α and GSK-3β. GSK-3 is active in cells under resting conditions and is primarily regulated through inhibition or diversion of its activity.

In this study, the mechanism that the inhibition of glycogen synthase kinase-3β (GSK-3β) promotes the production of reactive oxygen species (ROS) via β-catenin/CCAAT/enhancer binding protein α (C/EBPα) signaling was investigated in the spleen of zebrafish (Danio rerio).

May 1, 2018 · In this study, the mechanism that the inhibition of glycogen synthase kinase-3β (GSK-3β) promotes the production of reactive oxygen species (ROS) via β-catenin/CCAAT/enhancer binding protein α (C/EBPα) signaling was investigated in the spleen of zebrafish (Danio rerio).

Dec 1, 2022 · EcGSK3β significantly downregulated the activities of interferon-β, interferon-sensitive response element, and NF-κB. Taken together, these findings are important for a better understanding of the function of GSK3β in fish and reveal its involvement in the host response to viral immune challenge.

For the function of GSK-3β in fish hepatic lipid deposition remains unknown, it is essential to investigate whether GSK-3β/β-catenin signaling is involved in lipogenesis. The results will be helpful to explain the mechanism of lipid deposition in fish liver.

LOVAZA® uses a 5-step purification process that helps remove mercury and other environmental toxins that can be present in over-the-counter fish oil. Each 1-gram capsule of LOVAZA® contains 465 mg EPA and 375 mg DHA. EPA and DHA are the …

May 30, 2020 · DHA-rich fish oil supplementation significantly reduced the GSK-3β levels in individuals with obesity, a key kinase that is linked to the pathogenesis of T2D and AD. This suggests that fish oil enriched in DHA may be a potential early intervention option to reduce the chances of developing metabolic disease in high-risk individuals.

Aug 1, 2023 · Neodymium inhibits GSK-3β/Nrf2 signaling in the gill of zebrafish. Neodymium affects the generation of ROS via GSK-3β/Nrf2 signaling. Rare earth element neodymium (Nd) is widely used in industry and agriculture, which may result in the pollution of aquatic environment. In this study, we exposed zebrafish with 10, 50, and 100 μg/L Nd for four weeks.