For PVI with GP ablation, mapping can be used to locate gaps in ablation lines to test for electrical block in targeted areas [124]. Epicardial access for GP ablation with PVI yielded a rate of freedom from AF ranging from anywhere between 65% and 90% [121, 126].

The addition of GP ablation to PVI was associated with reduced arrhythmia recurrence. Adjunctive GP ablation was more effective in paroxysmal AF and in patients with smaller atria.

High frequency stimulation of atrial ganglionated plexi (GPs) may cause an increase in ERP dispersion and induce AF. Autonomic modification strategies by targeting GPs with catheter ablation have emerged as new targets.

Several pooled analyses, including a recent RCT-only meta-analysis, have found that GP ablation as an additive strategy to standard PVI may be more beneficial in patients with paroxysmal rather than persistent AF.

Ganglionated plexus (GP) ablation was shown to be effective at preventing atrial fibrillation (AF) in the GANGLIA-AF trial. Recurrence of symptomatic AF after pulmonary vein isolation (PVI) is usually treated by redo-PVI. It is not known if additional autonomic modification is beneficial.

Feb 6, 2025 · Common ablation techniques include linear ablation, ablation of complex fractionated atrial electrograms (CFAEs), ablation of the left atrial posterior wall, ablation of low-voltage areas (LVAs), ablation of extra-PV AF triggers, and ganglionated plexi (GP) ablation.

PVI+GP ablation confers superior clinical results with less ablation-related left atrial flutter and reduced AF recurrence compared to PVI+LL ablation at 3 years of follow-up.

Ganglionic plexus (GP) ablation, when added to pulmonary vein isolation (PVI) to treat atrial fibrillation (AF), may reduce AF recurrence. A meta-analysis of randomized controlled trials (RCT’s) comparing GP+PVI to PVI alone was performed among patients with AF. The primary outcome was recurrence of AF after ablation.

To improve outcomes, ablation targeting the left atrial substrate that maintains fibrillation is often added to pulmonary vein isolation (PVI), with ganglionated plexi (GP) and complex fractionated atrial electrograms (CFAE) ablation respectively targeting major GPs around pulmonary veins and complex atrial signals.

Apr 13, 2022 · Adjunctive ganglionic plexus (GP) ablation may increase the efficacy of pulmonary vein isolation (PVI) for treatment of atrial fibrillation (AF). Prior meta-analyses examining PVI with adjunctive GP ablation have included non-randomized trials and have included trials evaluating thorascopic epicardial ablation.