Apr 17, 2023 · Proton pump inhibitors (PPIs) reduce the production of acid by the stomach. They work by irreversibly blocking an enzyme called H+/K+ ATPase which controls acid production.

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May 31, 2024 · Gastroesophageal reflux disease – PPIs are indicated in patients with gastroesophageal reflux disease, including for the treatment of erosive esophagitis and as maintenance therapy in patients with severe erosive esophagitis or Barrett’s esophagus.

Dec 17, 2019 · PPIs are FDA-approved and indicated for the eradication of H pylori (when used with antibiotics). PPIs in combination with amoxicillin and clarithromycin for 7 to 14 days (termed PPI-based triple therapy) have historically been the standard first-line therapy option for the treatment of PUD associated with H pylori infection.

The purpose of this review is to evaluate the risks associated with long-term use of proton pump inhibitors (PPIs), focusing on long-term use of PPIs for three common indications: gastroesophageal reflux disease (GERD), Barrett’s esophagus (BE), and non-steroidal anti-inflammatory drug (NSAID) bleeding prophylaxis.

Sep 27, 2017 · We analyzed data from randomized clinical trials that performed pH testing in patients receiving solid-dose PPI formulations (omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole) for a minimum of 5 days.

Aug 19, 2024 · American College of Gastroenterology and American Gastroenterological Association had recent update in 2022 to PPI indication and recommendation for deprescribing. A comprehensive deprescribing protocol can assist in deprescribing of unnecessary PPIs.

Mar 9, 2024 · Proton pump inhibitors (PPIs) are among the most frequently used medications in the United States and worldwide. 1 PPIs inhibit gastric acid secretion by binding to the hydrogen-potassium adenosine triphosphatase enzyme system on parietal cells, 1 and are often used as an empiric trial for a constellation of symptoms including heartburn, chest p...

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