The glucagon-like peptide-1 receptor (GLP1R) is a G protein-coupled receptor (GPCR) found on beta cells of the pancreas and on neurons of the brain. It is involved in the control of blood sugar level by enhancing insulin secretion.

Sep 18, 2024 · The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell...

These multiple effects have generated a great deal of interest in the discovery of long-lasting agonists of the GLP-1 receptor (GLP-1R) in order to treat type 2 diabetes. This review article summarizes the literature regarding the discovery of GLP-1 and its physiological functions.

Feb 29, 2024 · GLP-1 agonists (also known as GLP-1 receptor agonists, incretin mimetics, or GLP-1 analogs) represent a class of medications used to treat T2DM and, in some cases, obesity. Examples of drugs in this class include Exenatide, Liraglutide, Dulaglutide, and Semaglutide.

Glucagon-like peptide-1 receptor (GLP-1R), a class B1 G protein-coupled receptor, plays critical roles in glucose homeostasis. Recent structural pharmacology studies using cryogenic electron microscopy, X-ray crystallography, mass spectrometry, and functional analyses, have provided valuable insights into its activation by endogenous hormones and mono- or dual agonists like semaglutide and ...

This review will encompass the synthesis, secretion, and metabolism of GLP-1, the structure and expression of the GLP-1r, the intracellular signaling initiated by GLP-1r stimulation, and GLP-1 changes after bariatric surgery.

Oct 9, 2023 · The glucagon-like peptide-1 receptor (GLP-1R) is a validated target for the treatment of diabetes and obesity, but drugs that target this receptor are a frequent cause of adverse events.

3 days ago · The development of GLP-1R agonists (GLP-1RAs) have revolutionized therapeutic strategies for metabolic disorders ().Exenatide, the first FDA-approved GLP-1RA (2005), established a proof-of-concept for peptide-based GLP-1R agonism and catalyzed the development of more effective agents with improved pharmacokinetic profiles (Figure 1A).Liraglutide was the second GLP-1RA approved for T2DM in 2010 ...

Mar 9, 2020 · GLP-1 acts on the GLP-1 receptor (GLP-1R) to lower blood glucose through enhanced glucose-dependent secretion of insulin, inhibition of glucagon secretion and slowed gastric emptying. It lowers...

Dec 2, 2024 · What is GLP-1R? Glucagon-like peptide-1 receptors (GLP-1Rs) belong to the large family of G protein-coupled receptors whose activation triggers a cascade of intracellular events through associated G proteins.