Download scientific diagram | GI 50 range plot of the tested compounds from publication: Antioxidant, antiproliferative, and acetylcholinesterase inhibition activity of amino alcohol...

Interactive Parallel Coordinates Plot for NCI60 Cell Line GI50 Profile of 15 Drugs

In the “iFad” model (an integrative factor analysis model for drug–pathway association inference), gene expression dataset is denoted as matrix Y1, with dimension G1 by J where G1 is the number of genes and J is the sample size. The paired GI50 dataset is denoted by matrix Y2, with dimension G2 by J where G2 is the number of drugs.

Box-plot of the concentration of drug causing 50% growth inhibition (GI50) for all 39 cell lines and eight therapeutics. The whiskers extend to 1.5 times the height of the box (i.e. 25th...

We address this question graphically in Figure 4, which plots the GI50 values against the TGI values, coloring or circling the chosen cell lines. Although they identify 7 sensitive cell lines and we identify 8, only 4 cell lines are on both lists.

A volcano plot shows the average IC 50 shift between mutant and non-mutant cell lines and the statistical significance of that difference. The power of the volcano analysis is that it allows simultaneous testing of changes in many validated cancer genes.

We designed a statistical analysis to associate experimental data (compound response (GI 50), gene/protein expression or protein phosphorylation) with cancer lineages or genotypes (i.e., mutations).

Jan 1, 2016 · Results: We modelled the 50% growth inhibition bioassay end-point (GI50) of 17,142 compounds screened against 59 cancer cell lines from the NCI60 panel (941,831 data-points, matrix 93.08% complete) by integrating the chemical and biological (cell line) information.

In an alternative method of viewing the data, the mean log GI 50, TGI, or LC 50 is placed as the center point of the so-called mean graph, and the individual values for a particular cell line are plotted as deflections from the mean.

(A) Plot comparing the GI50, retrieved from the NCI-60 cell lines (Table 1) and the values calculated by multiple regression analysis (GI50 (obs)). Equations used to calculate GI50are shown in...