Gamma delta T cells (γδ T cells) are T cells that have a γδ T-cell receptor (TCR) on their surface. Most T cells are αβ (alpha beta) T cells with TCR composed of two glycoprotein chains called α (alpha) and β (beta) TCR chains.

Apr 24, 2024 · These findings reveal organizing principles of the γδ TCR–CD3 complex, providing insights into the unique properties of γδ TCR and facilitating immunotherapeutic interventions.

There are 2 populations of T lymphocytes, αβ T and γδ T cells, that can be distinguished by the expression of either an αβ TCR or a γδ TCR, respectively.

Jul 24, 2020 · To date, diverse and largely host-cell-derived molecules have been identified as cognate antigens for the γδ TCR. However, for most γδ TCRs, the activating ligand is still unknown and many open...

Nov 22, 2023 · In contrast, γδ T cells adopt an alternative T cell receptor (TCR) architecture, consisting of γ and δ chains, granting them the ability to perceive a wider array of antigens in MHC-independent...

Gamma delta (γδ) T cells are the prototype of ‘unconventional’ T cells and represent a relatively small subset of T cells in peripheral blood. They are defined by expression of heterodimeric T-cell receptors (TCRs) composed of γ and δ chains.

Gamma-delta (γδ) T cells are an important subset of “unconventional” T lymphocytes as they have the ability to recognize a broad range of antigens without the presence of major histocompatibility complex (MHC) molecules.

May 6, 2018 · γδ T-cells straddle the innate and adaptive arms of the immune system and are involved in response to pathogens [e.g., mycobacteria; cytomegalovirus (CMV)] and tumors. Similar to αβ T-cells, γδ T-cells develop in the thymus, but express a rearranged T-cell receptor (TCR) consisting of a TCR-γ and a TCR-δ chain (1).

In this review, we will discuss the current state of knowledge of the molecular mechanism of TCR signal transduction and its role in the thymic development of γδT cells, particularly highlighting a newly discovered mechanism that controls proinflammatory γδT cell development. Keywords: γδT cell, Thymus, TCR signal Background

gd T cells are a prominent epithelial-resident lymphocyte population, possessing multi-functional capacities in the repair of host tissue, pathogen clearance, and tumor surveillance. Although three decades have now passed since their discovery, the nature of gd T cell receptor (TCR)-mediated ligand recognition remains poorly de-fined.