Complex functions of Gcn5 and Pcaf in development …
Understanding the functions of GCN5/PCAF in developmental processes provides clues to the roles of these KATs in disease states. Here we will review what is currently known about the developmental roles of GCN5 and PCAF, …
Opposite effects of GCN5 and PCAF knockdowns on the …
Here, we show that the depletion of GCN5 or PCAF in ALT cell lines induces differential effects on some ALT features, which suggests that GCN5 down-regulates ALT through its interactions …
Posttranslational regulation of the GCN5 and PCAF ... - PubMed
Sep 15, 2022 · General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone …
- Studies of GCN5 Pcaf
Posttranslational regulation of the GCN5 and PCAF …
Sep 22, 2022 · General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-associated factor (PCAF), are lysine acetyltransferases that modify both histone …
Modulating PCAF/GCN5 Immune Cell Function …
Sep 10, 2018 · Our data illustrate the power of the PROTAC approach in the context of multidomain proteins, revealing a novel anti-inflammatory …
- Author: Zuni I. Bassi, Martin C. Fillmore, Afjal H. Miah, Trevor D. Chapman, Claire Maller, Emma J. Roberts,...
- Publish Year: 2018
Complex functions of Gcn5 and Pcaf in development and disease
Feb 1, 2021 · Gcn5 null embryos are defective in somitogenesis and neurulation, whereas Pcaf null mice show a complete lack of developmental phenotypes. Hypomorphic mutations that …
- Author: Evangelia Koutelou, Aimee T. Farria, Sharon Y.R. Dent
- Publish Year: 2021
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Crystal structure of GCN5 PCAF N-terminal domain reveals
Oct 23, 2020 · General control nonderepressible 5 (GCN5, also known as Kat2a) and p300/CBP-associated factor (PCAF, also known as Kat2b) are two homologous acetyltransferases. Both …
Distinct roles of GCN5/PCAF‐mediated H3K9ac and …
Dec 3, 2010 · Using GCN5/PCAF double knockout (DKO) cells and CBP/p300 DKO cells, we determined the substrate and site specificities of these two distinct families of HATs in cells and show that GCN5/PCAF and CBP/p300 are …
Protein acylation: mechanisms, biological functions and …
Dec 29, 2022 · CDK5 acetylation at K33 by general control nonrepressed-protein 5 (GCN5) leads to the loss of its kinase activity via impairing the ATP binding, negatively regulating neurite …
Complex functions of Gcn5 and Pcaf in development and disease
Understanding the functions of GCN5/PCAF in developmental processes provides clues to the roles of these KATs in disease states. Here we will review what is currently known about the …
