The yeast Gcn5 (general control nonderepressible-5) HAT is one of the best-characterized members of this family. It has four functional domains, including an N-terminal domain, a highly conserved catalytic (HAT) domain, an Ada2 interaction domain, and a C-terminal bromodomain.

Mar 6, 2023 · In this study, we identify a GCN5-containing HAT complex, PAGA, in Arabidopsis and rice. The PAGA complex is distinct from the SAGA, ATAC and ADA complexes in eukaryotes and represents a...

Jan 15, 2021 · General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase (HAT) and lysine acetyltransferase (KAT).

Highly homologous with the PCAF HAT domain are the GCN5 proteins from various species. The crystal structure of the HAT domain of yeast GCN5 (yGCN5) was solved in absence of substrates , whereas the solution structure of the Tetrahymena GCN5 HAT domain (tGCN5) has been solved with NMR spectroscopy as a complex with CoA .

In human cell lines, HAT inhibitors and selective RNAi‐mediated Gcn5 or Ngg1 knockdown reduced the levels of aging markers and promoted proliferation in senescent cells. Furthermore, this observed lifespan extension was associated with …

May 8, 2023 · The histone acetyltransferase (HAT) subunit of coactivator complex SAGA, Gcn5, stimulates eviction of promoter nucleosomes at certain highly expressed yeast genes, including those activated by transcription factor Gcn4 in amino acid-deprived cells; however, the importance of other HAT complexes in t …

Jul 3, 2020 · SAGA (Spt-Ada-Gcn5 acetyltransferase) is a eukaryotic transcription coactivator complex that controls transcription by modifying histones. The story of SAGA started with the discovery of that the...

Feb 1, 2021 · The first nuclear histone acetyltransferase (HAT) characterized was General Control Non-derepressible 5 (Gcn5). Gcn5 was subsequently identified as a subunit of the HAT module of the Spt-Ada-Gcn5-acetyltransferase (SAGA) complex, which is an experimental paradigm for multifunctional co-activators.

Mar 30, 2025 · KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009] See ...

Jul 16, 2013 · Gcn5 belongs to a family of histone acetyltransferases (HATs) that regulate protein function by acetylation. Gcn5 plays several different roles in gene transcription throughout the genome but their characterisation by classical mutation approaches is hampered by the high degree of apparent functional redundancy between HAT proteins.