GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes. [5][6][7]

Dec 2, 2024 · Differentiate acute leukemias with T cell differentiation (GATA3+) from acute myeloid leukemia (< 10% GATA3+) and B lymphoblastic leukemias (GATA3-) (Hum Pathol 2017;65:166)

A recent study found GATA-3 to be associated with favorable breast cancer pathologic features, including negative lymph node and positive estrogen receptor (ER) status. GATA-3 levels were also found to be an independent prognostic marker, with low expression predicting for breast cancer recurrence.

GATA3 is a useful marker in characterization not only mammary and urothelial but also for renal and germ cell tumors, mesotheliomas, and paragangliomas. The multiple specificities of GATA3 should be taken into account when using this marker …

GATA-3 is particularly important in the development of T cells and is a key regulator in the immune system, influencing the development of the Th2 (T helper 2) cell lineage, which is involved in the immune response to parasites and allergic reactions.

In immune cells, GATA3 is best known to function as a master regulator of T helper 2 (T H 2)-cell differentiation. However, in recent years GATA3 has been found to have additional...

GATA3 has conventionally been regarded as a transcription factor that drives the differentiation of T helper (Th) 2 cells. Increasing evidence points to function for GATA3 beyond controlling Th2 differentiation. GATA3 regulates T cell development, proliferation and maintenance.

GATA binding protein 3 (GATA3), a member of the GATA family transcription factors, is a key player in various physiological and pathological conditions. It is known for its ability to bind to the DNA sequence “GATA”, which enables its key role in ...

Mar 30, 2025 · GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome and Hypoparathyroidism-Deafness-Renal Disease Syndrome.

Studies have shown that GATA3 has a critical role in the development of epithelial structures in both embryonic and adult tissues. The majority of studies regarding GATA3 expression in tumor evaluation focused on breast and urothelial neoplasms, whether primary or metastatic.