The term G4 DNA was originally reserved for these tetramolecular structures that might play a role in meiosis. [5] However, as currently used in molecular biology, the term G4 can mean G-quadruplexes of any molecularity.

Apr 20, 2020 · Experiments using chemical, molecular and cell biology methods have demonstrated that G4s exist in chromatin DNA and in RNA, and have linked G4 formation with key biological processes ranging...

Endogenous DNA G-quadruplex (G4) structures have been detected in human cells and mapped in genomic DNA and in an endogenous chromatin context by adapting next-generation sequencing approaches, to reveal cell type- and cell state-specific G4 landscapes and a strong link of G4s with elevated transcription.

Among these structures are G-quadruplex DNA structures (G4s), which support cellular function by affecting transcription, translation, and telomere maintenance. These structures can also induce genome instability by stalling replication, increasing DNA damage, and …

DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4) structures form through self-recognition of guanines into stacked tetrads, and considerable biophysical and structural evidence exists for G4 formation in vitro.

Aug 30, 2021 · G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated that G4 DNA structures exist both in cell-free and cellular systems, and function in different diseases, especially in various cancers, aging …

Feb 22, 2017 · Single-stranded guanine-rich DNA sequences can fold into stable intramolecular and intermolecular four-stranded non-B DNA structures called G-quadruplexes (G4s) 1 (Fig. 1). G4s arise from...

We propose that G4 motifs and structures that participate in key processes compose the G4 genome, analogous to the transcriptome, proteome, or metabolome. This is a new view of the genome, which sees DNA as not only a simple alphabet but also a more complex geography.

Apr 18, 2013 · We propose that G4 motifs and structures that participate in key processes compose the G4 genome, analogous to the transcriptome, proteome, or metabolome. This is a new view of the genome, which sees DNA as not only a …

5 days ago · a, G4switch, a photoswitchable binder of DNA G4s, remains in the ‘OFF’ bent state (cis) in the dark or after green light deactivation at 525 nm, which does not favour G4–G4switch binding ...