Guideline-directed medical therapies (GDMT) are under-prescribed in heart failure with reduced ejection fraction (HFrEF) patients who have concomitant chronic kidney disease (CKD) or end-stage kidney disease (ESKD) in both the inpatient and outpatient settings 1,2, despite the established benefit of GDMT in reducing cardiovascular mortality ...

In any patient with a history of congestion, maintenance diuretics should be considered to avoid recurrent symptoms. The treatment goal of diuretic use is to eliminate clinical evidence of fluid …

Central Illustration: First line Guideline Directed Medical Therapy (GDMT) having class I recommendations in the 2022 AHA/ACC/HFSA guidelines for Heart Failure with Reduce Ejection Fraction (HFrEF) as well as second line therapies with class IIa and IIb recommendations.

Sep 20, 2023 · Starting SGLT2 inhibitors and MRAs together may provide a buffer against hyperkalemia. As CKD progresses to stage 3, using these medications becomes increasingly challenging! However, these medications slow the decline in …

Sep 27, 2022 · Reviewing the physiologic basis of GDMT and exploring each drug’s mechanism of action and unique properties can enable careful initiation and titration of therapy, even in patients with...

According to the 2022 American College of Cardiology/American Heart Association/Heart Failure Society of America heart failure (HF) guidelines, initiation of quadruple therapy with renin-angiotensin-system inhibitors including angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blockers (ARBs)/angiotensin and neprilysin inhibitor...

Rapid sequence implementation of “kidney GDMT” Considerations: Assumes all patients with CKD are at equally high-risk, cost-effectiveness uncertain, and safety largely untested

Oct 4, 2022 · Predicted Probability of higher guideline-directed medical therapy (GDMT) goal attainment by chronic kidney disease (CKD) group. The panels represent the trajectories of attaining the represented total number of GDMT goals at …

Introduction: Guideline-directed medical therapy (GDMT) is imperative to improve cardiovascular and limb outcomes for patients with critical limb ischemia (CLI), especially amongst those at highest risk for poor outcomes, including those with comorbid chronic kidney disease (CKD).

Apr 1, 2025 · Novel therapies have revolutionized the care of patients with CKD + T2DM and provide an opportunity to meaningfully improve disease outcomes. GDMTs are evidence-based, proven approaches that can be implemented to manage CKD + T2DM. Despite availability, adherence to GDMT is low and multifactorial.