FVB is an albino, inbred laboratory mouse strain that is named after its susceptibility to Friend leukemia virus B. [1] This strain was produced from mice established at the National Institutes of Health in 1935. [2] .

FVB mice are a strain of laboratory mice that are commonly used in biomedical research. They were originally developed in the 1980s and are known for their high reproductive rates and susceptibility to developing certain tumors.

001800 FVB/NJ FVB/NJ are a widely used multipurpose inbred strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ are commonly used for transgenic injection. FVB/NJ mice are homozygous for the retinal degeneration 1 allele of Pde6b rd1 , resulting in blindness by wean age.

Strain is useful for the production of transgenic mice on a fully inbred genetic background. They have a vigorous reproductive performance with large litters.

Mar 17, 2025 · FVB mice are widely used in biomedical research due to their genetic uniformity and efficiency in generating transgenic models. Their large pronucleus in fertilized oocytes simplifies DNA microinjection, making them one of the …

Aug 23, 2012 · The FVB/NJ mouse has several distinct characteristics, such as large pronuclear morphology, vigorous reproductive performance, and consistently large litters that make it highly desirable for transgenic strain production and general purpose use.

FVB/N mice have been found to be useful for the generation of transgenic mouse strains due to large eggs for ease of microinjection, and large litter sizes. 33 Biologically relevant differences have also been described between the C57BL/6 and the FVB/N in the development of diabetes and obesity. 34 , 35 Recently, immunological differences have b...

FVB mice are ideal for generating transgenic mouse models, with prominent pronuclei for transgene microinjection and high reproductive performance.

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FVB/N mice are very active and develop a mild hyperthermia under stress. The FVB/N strain does not develop spontaneous tumours and shows a certain resistance to the chemical induction of papillomas, which, when they do appear, most of the time progress to carcinomas.