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Oct 16, 2011 · We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative demethylation activity targeting the abundant N 6-methyladenosine (m 6 A) residues in RNA in vitro. FTO...

Aug 8, 2020 · Here we show that FTO expression is suppressed in ovarian tumors and cancer stem cells (CSC). FTO inhibited the self-renewal of ovarian CSC and suppressed tumorigenesis in vivo, both of which required FTO demethylase activity.

Jun 23, 2021 · Here, we report widespread FTO downregulation in epithelial cancers associated with increased invasion, metastasis and worse clinical outcome. Both in vitro and in vivo, FTO silencing promotes...

Jul 11, 2018 · Here, we show that the FTO (fat mass and obesity-associated protein), an m6A demethylase, plays a critical role in cardiac contractile function during homeostasis, remodeling, and regeneration.

Mar 19, 2021 · FTO-mediated regulation of m 6 A m marking constitutes a reversible pathway controlling CSC abilities. Altogether, our findings bring to light the first biological function of the m 6 A m...

We summarize screening methods used to identify FTO modulators, techniques used to assess the biological effects of these modulators, strategies used to achieve selective inhibition of FTO rather than its homologues, and the results of investigations of FTO modulator modes of action and anticancer efficacy.

Nov 2, 2023 · Our current findings provided valuable insights into the role of FTO-mediated m 6 A demethylation modification in NSCLC metastasis. FTO was identified as a contributor to NSCLC metastasis through the activation of the FAP/integrin/FAK signaling, which may be a potential therapeutic target for NSCLC.

Effects of F/Sn atomic ratios on structural-morphological, compositional, electrical, optical, and nanomechanical properties of the FTO thin films were systematically studied.

Nov 22, 2024 · In this paper, fluorine doped tin oxide thin films were developed which exhibit excellent plasmonic behaviour in near infrared region. To investigate the optimum coating, the films with various dopant concentrations were prepared using the spray coating route.